Browsing by Author "Ferreira, Joana"
Now showing 1 - 10 of 10
Results Per Page
Sort Options
- Co-inheritance of alpha-thalassemia and sickle cell disease in a cohort of Angolan pediatric patientsPublication . Santos, Brígida; Delgadinho, Mariana; Ferreira, Joana; Germano, Isabel; Miranda, Armandina; Arez, Ana Paula; Faustino, Paula; Brito, MiguelThe aim of this study was to explore the association between alpha-thalassemia, fetal hemoglobin, hematological indices, and clinical adverse events in Angolan sickle cell disease pediatric patients. A total of 200 sickle cell disease (SCD) children were sampled in Luanda and Caxito. A venous blood sample was collected and used for hematological analyses, fetal hemoglobin quantification, and genotyping of 3.7 kb alpha-thalassemia deletion by GAP-PCR. The frequency of the 3.7 kb alpha-thalassemia deletion in homozygosity was 12.5% and in heterozygosity was 55.0%. An increase in alpha-thalassemia frequency was observed in children older than 5 years old (11.7% vs. 13.00%). Furthermore, 3.7 kb alpha-thalassemia deletion homozygotes had a significantly higher age of the first manifestation, lower number of blood transfusions by year, higher hemoglobin, lower mean corpuscular volume, mean corpuscular hemoglobin, and lower hemolytic rate observed by a lower number of reticulocytes count. There were no differences in fetal hemoglobin between the three genotypes. Moreover, the number of stroke events, osteomyelitis, splenomegaly, splenectomy, and hepatomegaly were lower when alpha-thalassemia was co-inherited. For the first time in the Angolan population, the effect of alpha-thalassemia deletion in sickle cell disease was analyzed and results reinforce that this trait influences the hematological and clinical aspects and produces a milder phenotype.
- Educação Artística: processos e desafios de cidadaniaPublication . Antunes, Sandra Sofia Pereira; Ferreira, Joana; Matos, JoanaO presente artigo incide sobre princípios, processos e práticas de educação artística e estética, desenvolvidos na Unidade Curricular (UC) de Artes Plásticas II, do 2º ano da Licenciatura em Educação Básica, na Escola Superior de Educação do Politécnico de Lisboa. Na formação de agentes capacitados para a intervenção em âmbitos da ação educativa, em contextos formais e não formais, despertar o futuro agente educativo para o potencial transformador da educação artística e estética (seja este em termos culturais, sociais, ambientais...), tem-se constituído como um objetivo do grupo interdisciplinar de docentes (das ciências da arte, da educação artística, do design e das ciências da educação) responsáveis pela UC. Neste sentido, fazer compreender processos criativos e artísticos como processos investigativos e a suas práticas como socialmente construídas, integradoras e transformadoras do indivíduo e consequentemente do tecido social, interrelacionando a escola, a sociedade e a arte, tem sido nossa preocupação recorrente.
- Efficacy and safety of pharmacological interventions for managing sickle cell disease complications in children and adolescents: systematic review with network meta‐analysisPublication . Tonin, Fernanda; Ginete, Catarina; Ferreira, Joana; Delgadinho, Mariana; Santos, Brígida; Fernandez‐Llimos, Fernando; Brito, MiguelThis study aimed to synthesize the evidence on the effects of disease-modifying agents for managing sickle cell disease (SCD) in children and adolescents by means of a systematic review with network meta-analyses, the surface under the cumulative ranking curve (SUCRA) and stochastic multicriteria acceptability analyses (SMAA) (CRD42022328471). Eighteen randomized controlled trials (hydroxyurea [n = 7], l-arginine [n = 3], antiplatelets [n = 2], immunotherapy/monoclonal antibodies [n = 2], sulfates [n = 2], docosahexaenoic acid [n = 1], niprisan [n = 1]) were analyzed. SUCRA and SMAA demonstrated that hydroxyurea at higher doses (30 mg/kg/day) or at fixed doses (20 mg/kg/day) and immunotherapy/monoclonal antibodies are more effective for preventing vaso-occlusive crisis (i.e., lower probabilities of incidence of this event; 14, 25, and 30%, respectively), acute chest syndrome (probabilities ranging from 8 to 30%), and needing of transfusions (11-31%), while l-arginine (100-200 mg/kg) and placebo were more prone to these events. Therapies were overall considered safe; however, antiplatelets and sulfates may lead to more severe adverse events. Although the evidence was graded as insufficient and weak, hydroxyurea remains the standard of care for this population, especially if a maximum tolerated dose schedule is considered.
- Efficacy and safety of pharmacological interventions for managing sickle cell disease in children and adolescents: protocol for a systematic review with network meta-analysisPublication . Tonin, Fernanda; Ginete, Catarina; Fernandez-Llimos, Fernando; Ferreira, Joana; Delgadinho, Mariana; Brito, MiguelIntroduction: Sickle cell disease (SCD), an inherited haemoglobinopathy, has an important impact on morbidity and mortality, especially in paediatrics. Previous systematic reviews are limited to adult patients or focused only on a few therapies. We aim to synthesise the evidence on the efficacy and safety of pharmacological interventions for managing SCD in children and adolescents. Methods and analysis: This systematic review protocol is available at Open Science Framework (doi:10.17605/OSF.IO/CWAE9). We will follow international recommendations on the conduction and report of systematic reviews and meta-analyses. Searches will be conducted in PubMed, Scopus, and Web of Science (no language nor time restrictions) (first pilot searches performed in May 2022). We will include randomised controlled trials comparing the effects of disease-modifying agents in patients with SCD under 18 years old. Outcomes of interest will include: vaso-occlusive crisis, haemoglobin levels, chest syndrome, stroke, overall survival, and adverse events. We will provide a narrative synthesis of the findings, and whenever possible, results will be pooled by means of pairwise or Bayesian network meta-analyses with the surface under the cumulative ranking curve analyses. Different statistical methods and models will be tested. Dichotomous outcomes will be reported as OR, risk ratio, or HR, while continuous data will be reported as standard mean differences, both with 95% CI/credibility interval. The methodological quality of the trials will be evaluated using the Risk of Bias 2.0 tool, and the certainty of the evidence will be assessed with the Grading of Recommendations Assessment, Development, and Evaluation approach. Ethics and dissemination: This study refers to a systematic review, so no ethics approval is necessary. We intend to publish our findings in an international, peer-reviewed journal. Data will also be presented to peers at scientific events. Additionally, the results obtained in this study may contribute towards the update of therapeutic guidelines and the development of health policies for SCD.
- Naturália, práticas comparadasPublication . Ferreira, Joana; Matos, Joana; Antunes, SandraConstituindo-se como a primeira abordagem às Artes Plásticas, oferecida aos estudantes de primeiro ano, da Licenciatura em Educação Básica, da ESELx, a Unidade Curricular na qual se integra o presente projeto fomenta a aquisição e a mobilização de conhecimentos de natureza técnica no âmbito de práticas bi e tridimensionais. Tendo por base o estudo da frottage, a realização que partilhamos, desenhou-se numa abordagem de índole projetual desenvolvida com estudantes de licenciatura e crianças do primeiro ciclo do Ensino Básico. Considerando a frottage como princípio gráfico e sígnico, de sentido táctil e icónico, foram convocados por via das práticas, conhecimentos históricos e plásticos, operacionalizaram-se elementos e princípios abstractos, foi produzida ação reflexiva e crítica, fomentou-se investigação fundada na prática, conceptualizou-se um projeto expositivo para a disseminação do conhecimento adquirido. A pretexto da análise dos personagens criados no século XVI por Jheronymus Bosch, organizou-se um mundo de formas imaginárias, de base material e cientificamente informada, ponto de partida para o conjeturar de outras perspectivas sobre a(s) realidade(s), fomentando a produção de pensamento reflexivo, desenvolvendo literacia e cultura visuais, alavancando ação projetual em educação, iniciação à investigação, e inovação.
- Pregnancy surveillance in sickle cell disease patients: a cohort study in an African country – AngolaPublication . Brito, Miguel; Ginete, Catarina; Ferreira, Joana; Mendes, Manuela; Vasconcelos, Jocelyne; Delgadinho, Mariana; Sebastião, Cruz; Quinto, Francisco; Simão, Fernanda; Mateus, Anabela; Fernandes, FilipeSickle Cell Disease (SCD) is a severe monogenic disease caused by the inherence of a recessive mutation in the β-globin gene, with an especially high prevalence in sub-Saharan Africa. In Angola, the prevalence of the disease is almost 2%, and the carriers reach 21% of the population. Although its presentation tends to be very heterogeneous, chronic hemolytic anemia, frequent painful crises, and extensive organ damage are common features of these patients. Pregnancy in SCD patients is associated with an increase in severe outcomes, namely, a high risk of eclampsia and pre-eclampsia, stroke, and even death. Therefore, it is crucial to maintain continuous medical surveillance during pregnancy, especially in women with previous strokes. Moreover, health services in low- and middle-income countries are generally not prepared to follow these patients. The present cohort study, conducted at the Lucrecia Paim Maternity Hospital (Luanda, Angola), aims to determine pregnancy complications in SCD women, especially those responsible for maternal death, and, by supporting the obstetric consultations in this hospital, contribute to the reduction of mortality and morbidity rates. Pregnancy monitoring includes analysis of clinical history and incidents (number of hospitalizations, blood transfusions, strokes, and other clinical complications), hematological and biochemical analysis, transcranial Doppler to assess cerebral hemodynamics, and genetic analysis (confirmation of the diagnosis, genotyping of four SNPs in the β-cluster to assess the haplotype, and evaluation of the presence of the 3.7kb deletion of the α-globin gene).
- Preventable exposure in routine chest CT examinations: evaluation of effective dose beyond prescribed anatomical landmarksPublication . Bárbara, Ana Rita; Ferreira, Joana; Lança, LuísObjective - Evaluate preventable exposure dose in routine chest CT examinations beyond prescribed anatomical landmarks and estimate extra dose delivered to the patient. Background/rationale - Recent technical advances have greatly increased the clinical applications of CT; developments in multidetector-row CT (MDCT) technology have occurred; the major disadvantage with the increased use of MDCT is associated radiation exposure.
- Processo criativo e prática pedagógica na formação do educador enquanto sujeito culturalPublication . Matos, Joana; Ferreira, Joana; Pereira, Teresa MatosEste texto incide sobre os processos inerentes à estruturação de planos curriculares nas Unidades Curriculares (UC) de Artes Plásticas I e II integradas na Licenciatura em Educação Básica (Escola Superior de Educação de Lisboa) nos anos letivos 2017/2018 e 2018/2019. Por um lado, aborda as bases de natureza teórica que possibilitaram a reformulação dos conteúdos e das metodologias de lecionação. Por outro, faz um balanço de algumas das práticas desenvolvidas no âmbito da implementação dos programas criados, considerando práticas docentes e práticas criativas levadas a cabo para o efeito.
- O projeto artístico-pedagógico como meio de pensar e construir a aprendizagemPublication . Ferreira, Joana; Matos, JoanaO projeto artístico-pedagógico, tem vindo a ser desenvolvido na Unidade Curricular de Artes Plásticas II da Licenciatura em Educação Básica, na Escola Superior de Educação de Lisboa como um meio de pensar e construir a aprendizagem. Enquadrado numa metodologia de trabalho assente em processos criativos no campo das artes plásticas, os projetos desenvolvidos têm vindo a promover a utilização de recursos de natureza diversa, processos de trabalho de pesquisa e integração de conhecimentos de natureza variada, traduzindo-se em abordagens que se valorizam sempre como resultado de caminhos pessoais e de descoberta. O desenvolvimento de processos criativos no campo das artes plásticas permite ainda perceber como estruturar as aprendizagens tendo em vista as práticas profissionais em contexto educativo formal e não formal. Pretende-se mostrar alguns dos processos de trabalho desenvolvidos, nomeadamente os processos criativos, entendidos enquanto método de investigação e pesquisa em educação artística, através de utilização de técnicas e ferramentas que tornam o pensamento mais visual e percetível, tais como o brainstorming ou o mindmap. Pretende-se ainda evidenciar que o processo de trabalho de natureza artística, como exercício de investigação multidisciplinar, promove um maior e mais ancorado envolvimento com o projeto em si mesmo, desenvolvendo simultaneamente o sentido crítico e criativo sobre os assuntos. Em termos de resultados, analisam-se alguns projetos exemplificativos que mobilizam conhecimentos de natureza técnica, estética e cultural tendo em conta as questões pedagógicas, como revisão e reflexão sobre as metodologias de trabalho desenvolvidas, cujos meios passam ainda pela utilização de recursos digitais.
- Urban mobility strategies to improve local air quality: case study of Lisbon, PortugalPublication . Almeida-Silva, Marina; Almeida, Susana Marta; Canha, Nuno; Faria, Marta; Baptista, Patrícia; Rafael, Sandra; Ferreira, Joana; Lopes, DiogoParticulate matter concentrations are still exceeding the European air quality limit values, mainly in the urban areas where a large part of the population lives. Despite the implementation of several policies and measures to reduce the atmospheric emissions from road transport, this activity still has a high influence on the air quality of the European cities. The main purpose of this study was to assess the potential of urban mobility strategies to reduce the particulate matter concentrations over the main avenue of Moscavide (a parish within the municipality of Loures, very close to the city of Lisbon, Portugal). The proposed strategies were evaluated by applying an air quality modeling system with a high spatial resolution. The results showed a slight air quality improvement (up to 0.9 μg.m-3) for the tested scenarios. However, complementary studies are still necessary to provide a better understanding of the most efficient urban mobility strategies to be applied over the study area.