RCIPL

Institutional Repository of the Lisbon Polytechnic

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The aim of this Scientific Repository is to disseminate the scientific production produced by the Instituto Politécnico de Lisboa academic community, to increase the visibility and the investigation impact, to ensure the storage of the intellectual memory and to promote the open access to the information.

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Recent Submissions

Não te deixes enganar! Projeto de literacia no combate à desinformação no ensino superior

Publication . Lopes, Carlos; Antunes, Maria Luz; Sanches, Tatiana

O projeto “Be careful!” assenta numa relação de confiança e parceria entre as bibliotecas, os seus profissionais, estudantes e investigadores. O objetivo é combater a dimensão académica e científica do fenómeno da desinformação e garantir a integridade académica, desenvolvendo melhores e mais apuradas competências para o estudo, investigação, publicação e divulgação do conhecimento científico. Para tal, serão traduzidos e adaptados instrumentos e ferramentas que melhorem a qualidade do trabalho académico através do reforço de critérios baseados na literacia da informação, quer na seleção da credibilidade das fontes, quer na aferição de critérios de qualidade das publicações científicas, quer na prevenção do plágio e de outras práticas académicas ilícitas.

2025-06Conference paper

Open access

Dissection of the microRNA transcriptomes of CD4+ T cell subsets in autoimmune inflammation identifies novel regulators of disease pathogenesis

Publication . Cunha, Carolina; Romero, Paula Vargas; Inácio, Daniel; Pais, Ana Teresa; Pelicano, Catarina; Costa, Marina; Mensurado, Sofia; Gonçalves-Sousa, Natacha; Papotto, Pedro H.; Neves, Daniel; Sobral, Daniel; Enguita, Francisco; Silva-Santos, Bruno; Gomes, Anita

MicroRNAs (miRNAs) are key regulators of CD4+ T cell differentiation, but how they contribute to the course of an autoimmune disease in vivo remains poorly studied. Given the known roles in autoimmunity of pro-inflammatory T helper 1 (Th)1 and Th17 cells, and anti-inflammatory Foxp3+ regulatory cells, we established a triple reporter mouse for Ifng, Il17 and Foxp3, and subjected it to experimental autoimmune encephalomyelitis (EAE) to characterize the miRNomes of the corresponding CD4+ T cell subsets. We identified 110 miRNAs differentially expressed between the pro-inflammatory (Th1 and Th17 cells) and the Treg cell subsets. Among these, we found novel functions for miR-122-5p and miR-1247 as regulators of Th17 cell proliferation and Th1 cell differentiation, thus impacting the course or severity of EAE, respectively. Importantly, their expression patterns suggest miR-122-5p and miR-1247 act as peripheral brakes to CD4+ T cell pathogenicity that are subverted in the inflamed central nervous system.

2025-06Preprint

Open access

Social and psychological determinants of COVID-19 vaccination intention in European and North American adults: a systematic review

Publication . Almeida-Silva, Marina; Vieira, Lina Oliveira; Grilo, Ana; Pedro, Luísa; Coelho, André; Carolino, Elisabete; Umanets, Oleksandra; Andrade, Graça

Since the beginning of the SARS-CoV-19 pandemic, tremendous efforts have been made to address this public health emergency of international concern. The control of the disease has essentially depended on vaccination programs. Many recent studies continue to explore the factors related to the COVID-19 vaccine acceptance. This systematic review was conducted following PRISMA guidelines. PubMed, Scopus, Web of Science, EBSCO, CINAHL, EMBASE, and PsycoINFO were searched to gather all relevant data on the social and psychological determinants of intention to vaccinate against COVID-19. The ROBIS tool was used to evaluate the risk of bias. The main objective of this systematic review was to identify the main social and psychological determinants responsible for the choice to vaccinate against COVID-19 in the adult population of Europe and North America. This systematic review examined literature identified through seven databases yielding 576 PRISMA records, yielding 28 articles. The results suggest that older people, higher education level, and Caucasians have a stronger intention to be vaccinated. Many studies confirm that beliefs about vaccine costs and benefits are related to vaccine intention. Social concerns, perceived severity of COVID-19, and perceived risk of being infected are confirmed in most studies as determinants of vaccination intention. Conspiracy beliefs seem to promote vaccine hesitance. The results point to some useful conclusions for promoting vaccination in future pandemic situations. In addition to the targeting of the most vaccine-resistant groups, this study suggests the main themes that should be focused on in future public communication to promote vaccination.

2025-05Journal article

Open access

Development and characterization of nutritious and sustainable canned fish meal prototype for different population segments

Publication . Oliveira, Helena; Cristóvão, Maria; Nabais, Alexandre; Camacho, Carolina; Sapatinha, Maria; Pires, Carla; Lourenço, Helena M.; Fernandes, Maria H.; Fernandes, Maria J.; Fraqueza, Maria J.; Augusto, Helga C.; Viegas, Cláudia; Duarte, Maria P.; Marques, António; Gonçalves, Amparo; Nunes, Maria L.

Canning is an excellent solution to provide convenient, affordable, nutritious, and safe seafood with a long shelf life. However, many canned products use tuna, sardines, and Atlantic chub mackerel, species that raise sustainability concerns and whose overuse can put additional pressure on them. Hence, this study aimed to i) develop and assess a nutritious and sustainable canned meal prototype using the Atlantic horse mackerel (Trachurus trachurus) (whose EU allowable-catch amounts have increased, particularly, in Iberian waters) and vegetables in light brine in terms of stability, sterility, and physicochemical and sensory properties over 4 months at room temperature and ii) evaluate its nutritional contribution for different population groups. After preparation, the meal was stored for one month at ≈20 °C and ≈40 °C (to simulate the 4 months). Although the pH was not stable, the meal was considered commercially sterile according to the challenge accelerated tests. Moreover, aging did not significantly affect the meal’s physicochemical and sensory properties. This innovative meal prototype can be claimed to be “low-fat”, “reduced in NaCl/Na”, a “source of protein, phosphorus, iron, selenium and vitamin D”, and “high in vitamin B12”. It proved to be both nutritious and appealing for consumption, with the potential to be scaled up.

2025-05Journal article

Open access

Critical insights on fungal contamination in schools: a comprehensive review of assessment methods

Publication . Cervantes, Renata; Pena, Pedro; Riesenberger, Bruna; Rodriguez, Margarida; Henderson, Drew; Gonçalves, Sara; Newire, Enas; Pogner, Clara; Salonen, Heidi; Almeida-Silva, Marina; Ferguson, Robert M.; Haverinen-Shaughnessy, Ulla; Viegas, Carla

This review addresses the increasing problem of fungal contamination in schools, which has a profound impact on indoor air quality and student health. Fungal contamination creates health problems such as respiratory problems, allergies, which can be particularly harmful in schools (e.g., Aspergillus fumigatus and Fusarium sp. are especially important as they are well-known indoor allergens and can induce serious respiratory diseases). This study aims to determine the effect of geographic location as well as season of filamentous fungi in the school context. Through a comprehensive screening of 6,659 articles, 47 studies were selected for data extraction, detailing sampling techniques, analysis methods, climatic conditions, and relevant fungal species. The study highlights the importance of regularly measuring IAQ and utilizing both active and passive sampling methodologies in addition to molecular genetic analysis to complement identification and improve comparability across studies. A targeted monitoring is also proposed for species such as Aspergillus fumigatus (Aspergillus section Fumigati), Fusarium sp., and Mucorales order, which are therapeutically relevant, as well as Stachybotrys atra and Aspergillus section Flavi, in terms of their toxicological potential. Additionally, the article discusses the importance of consistent data formatting for effective meta-analysis and the need for further research to inform regulatory frameworks protecting student health. Recommendations for minimizing fungal threats include evaluating building structure, ventilation, cleaning practices, and gathering information from parents about school activities. Overall, the study underscores the global health risks posed by fungi in schools and calls for extensive investigations combining various sampling and analytical techniques. Additionally, the article discusses the importance of consistent data formatting for effective meta-analysis and the need for further research to inform regulatory frameworks protecting student health. Recommendations for minimizing fungal threats include evaluating building structure, ventilation, cleaning practices, and gathering information from parents about school activities. Overall, the study underscores the global health risks posed by fungi in schools and calls for extensive investigations combining various sampling and analytical techniques.

2025-06Journal article

Open access