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Assessment of DNA damage and oxidative stress of green tea epigallocatechin-3-gallate (EGCG) by comet assay
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Orientador(es)
Resumo(s)
Introduction: EGCG, the primary polyphenol in green tea, has been shown to inhibit cancer cell growth and tumorigenesis in vitro and animal models, particularly by eliminating cancer cells through induction of apoptosis and protecting normal cells against genotoxic hazards. However, increasing evidence indicates that EGCG produces ROS. Aim of the study: Evaluate DNA damage and oxidative damage, measured by comet assay; lipid profile, liver function parameters, and vitamins A and E levels during an interventional study with 90 days (T0 and T90) duration (T0 and T90) in 30 individuals with an EGCG intake of 225 mg/day.
Descrição
Supported by H&TRC- Health & Technology Research Center- Escola Superior de Tecnologia da Saúde, Instituto Politécnico de Lisboa. H&TRC authors gratefully acknowledge the FCT/MCTES national support through the UIDP/05608/2020, and UIDB/05608/2020.
Palavras-chave
DNA damage Oxidative damage Green tea Epigallocatechin-3-gallate FCT_UIDP/05608/2020 FCT_UIDB/05608/2020
Contexto Educativo
Citação
Ladeira C, Ramos C, Pádua M, Ribeiro E. Assessment of DNA damage and oxidative stress of green tea epigallocatechin-3-gallate (EGCG) by comet assay. In: 52nd Congress of the European Environmental Mutagenesis and Genomics Society (EEMGS), Rovinj (Croatia), September 23-27, 2024.