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Advisor(s)
Abstract(s)
Background: Severe acute respiratory syndrome coronavirus 2 immunoglobulin G (SARS-CoV-2-IgG) antibodies have been widely used to assist clinical diagnosis and occupational exposure risks. Objectives: This study aimed to estimate SARS-CoV-2 IgG levels acquired due to different vaccination schemes. Materials and methods: A retrospective study was performed on volunteers from the Instituto Politécnico de Lisboa. Blood samples were collected and analyzed through the ELISA methodology and a statistical analysis was conducted. Results: Among study participants, the percentage of women was higher than men, with an average age of 39.02 years. 88.5% of individuals had an mRNA vaccination versus 11.5% for a viral vector vaccination. Moderna vaccine had the highest IgG titer (9.62 index), while the lowest titer was 5.97 index, obtained by the Janssen vaccine. Data from individuals with the 2nd vaccine dose corresponded to the highest percentage of seropositive titers (62.6%). Regarding the time between vaccination and sample collection, 41.9% were collected over six months and 2.2% between 1 and 2 months. Discussion: Data demonstrated that the vaccine technology, the period between vaccination and collection, and cross-vaccination have a significant impact on SARS-CoV-2 IgG levels. In conclusion, future assessment of individual immune responses and group immunity is crucial for occupational exposure and public health.
Description
This work was supported by Project COVID management and acquired immunity assessment in the IPL community (COVIDVax_IPL) funded by Instituto Politécnico de Lisboa (IPL). H&TRC authors gratefully acknowledge the FCT/MCTES UIDP/05608/2020, and UIDB/05608/2020.
Keywords
SARS-CoV-2 Vaccination schemes IgG index Occupational exposure Higher education Portugal Instituto Politécnico de Lisboa COVIDVax_IPL FCT_UIDP/05608/2020 FCT_UIDB/05608/2020
Citation
Almeida A, Oliveira K, Ribeiro E. SARS-CoV-2 immunization in academic community: vaccination schemes efficiency. In: Baptista JS, Melo RB, Carneiro P, Castelo Branco J, Costa N, Duarte J, et al. Occupational and environmental safety and health VI: occupational risk assessment, management and case studies (Vol. I). Cham: Springer; 2025. p. 193-203.
Publisher
Springer Nature