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Chemotherapy-associated cardiotoxicity in women with breast cancer: assessment of myocardial work index by transthoracic echocardiography

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Background: Breast cancer is one of the most common malignancies worldwide. Despite advances in treatment, these therapies can increase the risk of cardiotoxicity, making cardiac monitoring crucial in this population. The Myocardial Work Index (MWI) has emerged as a tool to predict the risk of cardiotoxicity. Using the left ventricular pressure-strain loop technique, MWI evaluates myocardial work and calculates global work index (GWI), global wasted work (GWW), global constructive work (GCW), and global work efficiency (GWE). Purpose: To determine the added value of myocardial work indices compared with global longitudinal strain (GLS) assessed by transthoracic echocardiography (TTE) in the diagnosis of chemotherapy-associated cardiotoxicity in women with breast cancer.

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Clinical physiology Transthoracic echocardiography Chemotherapy Breast cancer

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Sousa RM, Fonseca V, Azevedo C, Simão M, Cobas V, Matos A. Chemotherapy-associated cardiotoxicity in women with breast cancer: assessment of myocardial work index by transthoracic echocardiography. In: ESC Cardio-Oncology 2026, Vienna (Austria), June 19-20, 2026.

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