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- Chemotherapy-associated cardiotoxicity in women with breast cancer: assessment of left atrial strain by transthoracic echocardiographyPublication . Sousa, R. M.; Fonseca, Virgínia; Henriques, M.; Cavaco, S.; Silva, J.; Clérigo, Anália MatosBackground: Transthoracic echocardiography (TTE) is considered the gold-standard method for assessing cardiac function, with left ventricular ejection fraction (LVEF) and global longitudinal strain (GLS) being the main parameters used for early detection of cardiotoxicity. Left atrial (LA) strain represents the myocardial deformation of this structure and is assessed based on three main parameters, among which peak atrial longitudinal strain (PALS) stands out for best reflecting global LA function. Purpose: To evaluate left atrial strain by TTE as a predictor of cardiotoxicity at different stages of treatment with anthracyclines and trastuzumab in women with breast cancer.
- Chemotherapy-associated cardiotoxicity in women with breast cancer: assessment of myocardial work index by transthoracic echocardiographyPublication . Sousa, R. M.; Fonseca, Virgínia; Azevedo, C.; Simão, M.; Cobas, V.; Clérigo, Anália MatosBackground: Breast cancer is one of the most common malignancies worldwide. Despite advances in treatment, these therapies can increase the risk of cardiotoxicity, making cardiac monitoring crucial in this population. The Myocardial Work Index (MWI) has emerged as a tool to predict the risk of cardiotoxicity. Using the left ventricular pressure-strain loop technique, MWI evaluates myocardial work and calculates global work index (GWI), global wasted work (GWW), global constructive work (GCW), and global work efficiency (GWE). Purpose: To determine the added value of myocardial work indices compared with global longitudinal strain (GLS) assessed by transthoracic echocardiography (TTE) in the diagnosis of chemotherapy-associated cardiotoxicity in women with breast cancer.