Percorrer por data de Publicação, começado por "2026-06"
A mostrar 1 - 10 de 23
Resultados por página
Opções de ordenação
- Sparse mixture of experts enhanced transformer architecture for short-term hydroelectric reservoir volume predictionPublication . Seman, Laio Oriel; Yow, Kin-Choong; Stefenon, Stefano FrizzoIn hydroelectric-based systems, effective energy generation planning relies heavily on precise forecasting of reservoir water levels. This paper proposes a novel hybrid forecasting framework that integrates multiple preprocessing strategies with a sparse Mixture of Experts enhanced Transformer architecture for short-term reservoir volume prediction. When evaluated on 19 interconnected reservoirs across two major river basins in southern Brazil using real operational data from the Brazilian National System Operator, the proposed model achieves a mean squared error of 0.062 and a mean absolute error of 0.145. Comprehensive benchmarking against 18 state-of-the-art deep learning methods demonstrates that the proposed approach significantly outperforms existing methods while maintaining computational efficiency through sparse expert routing. Our results confirm that combining diverse preprocessing strategies with conditional computation mechanisms provides superior forecasting accuracy for reservoir management in hydroelectric power systems.
- Old molecules, new hope: a scoping review and bibliometric analysis of drug repurposing for lung cancerPublication . Ragassi, Wellington Martins; Alves, Fernando Miguel; Lazo, Raul Edison; Tonin, Fernanda; Pontarolo, Roberto; Sari, Marcel Henrique; Ferreira, Luana MotaDrug repurposing has gained prominence in oncology by enabling the investigation of approved drugs for new therapeutic purposes. In lung cancer, this strategy may reduce the time and costs associated with drug development. This study aimed to map the landscape of in silico, in vitro, in vivo, and clinical research on drug repurposing for lung cancer, while identifying key molecular targets and research gaps. A systematic search was conducted in PubMed, Embase, and Web of Science, following Joanna Briggs Institute and PRISMA-ScR guidelines. Two reviewers independently selected and extracted the data. A total of 58 studies, published between 2010 and 2024, mainly from the United Kingdom (19%) and the United States (17%), were included. Most studies used in vitro models (53%), followed by in vivo (31%) and in silico (16%), with frequent combinations of methods. The most investigated drug classes were antibiotics (10%), antipsychotics (9%), antidiabetics (8%), anthelmintics (6%), and antihistamines (6%). Frequently studied drugs included niclosamide, metformin, atorvastatin, and doxazosin, targeting pathways such as PI3K/AKT/mTOR, apoptosis, and autophagy. Bibliometric analysis revealed increasing scientific output, with emphasis on combination therapies, cellular mechanisms, and technologies like molecular docking and nanosystems. These findings highlight the growing relevance of drug repurposing in lung cancer, especially in accelerating effective therapy discovery using approved compounds. Progress in this field depends on integrating diverse methodologies and fostering interdisciplinary collaboration. As a next step, rigorous clinical trials are essential to confirm the efficacy and safety of promising repurposed agents in oncology.
- Aspergillus spp. in woodworking settings: implications for occupational health and safetyPublication . Dias, Marta; Rodriguez, Margarida; Riesenberger, Bruna; Marques, Liliana; Carolino, Elisabete; Twarużek, Magdalena; Kosicki, Robert; Gonçalves, Lídia; Caetano, Liliana Aranha; Alastruey-Izquierdo, Ana; Viegas, Susana; Viegas, CarlaWoodworkers are exposed to several potentially harmful agents, including microorganisms that grow in the wood. The most common fungal species in woodworking environments are Aspergillus, Penicillium, and Cladosporium spp., with occupational exposure to Aspergillus spp. posing a significant respiratory risk. This study aimed to assess exposure to Aspergillus spp. in two Portuguese woodworking environments and to perform a thorough analysis of Aspergillus fumigatus complex isolates collected from 13 DIY stores and 6 Carpentries in the Lisbon Metropolitan Area. Sampling combined active and passive methods to assess microbial contamination. Aspergillus fumigatus isolates were analysed for their antifungal susceptibility, resistant mechanisms, mycotoxin production, and cytotoxic potential in lung (A459) and liver (HepG2) cell lines. The MAS-100 presented Aspergillus sections Aspergilli and Flavi with the highest prevalence in DIY stores and Carpentries, respectively. A total of 1185 Aspergillus spp. were recovered, 270 identified as Aspergillus fumigatus sensu stricto growing at 37 °C. None of those isolates was resistant to azoles, 99.07% of them produced gliotoxin, and 39.9% of them produced cytotoxic effects in at least one cell line. This study comprehended a multi-approach that considered not only sampling methods but also the laboratory assays to be applied in the Aspergillus section Fumigati isolates recovered from two different woodworking environments, allowing a complete and robust analysis of this specific environment and species. Overall, the findings indicate that woodworkers are exposed to A. fumigatus isolates with relevant pathogenic traits, despite the absence of azole resistance, underscoring the need for continued environmental and occupational monitoring.
- LEARNER - A prospective, randomized controlled study to evaluate the effects of daily low dose aspirin in pregnant women with sickle cell disease when initiated at the first trimester versus the second trimester of the gestational period: study protocolPublication . Brito, Miguel; Ginete, Catarina; Gomes, Tatiana; Pitangueira, Helena; Mendes, Manuela; Furtado, Ana; Alves, Ligia; Simão, Fernanda; Gonçalves, Mauer; Morais, JoanaBackground: Pregnancy in women with Sickle Cell Disease (SCD) is associated with an increased risk of severe complications, such as eclampsia, pre-eclampsia, maternal death, intrauterine growth restrictions, perinatal mortality, and low birth weight. Since 50% of these patients are now living to reproductive age, the management of SCD during pregnancy has become pertinent. Searching for prophylactic and affordable measures for early prevention of these complications is urgently needed. Methods: A daily low dosage of Aspirin is widely used during pregnancy to prevent pre-eclampsia and other vascular disorders. But the lack of evidence of effectiveness in pregnant women with SCD leads to the need to develop clinical trials with this population. In this prospective controlled study, we intend to evaluate the effects of daily low-dose aspirin in pregnant women with SCD, testing the hypothesis that if daily use of low-dose aspirin is initiated early in pregnancy (between 6 and 13 weeks of gestation) versus in the second trimester (between 14 and 27 weeks of gestation), it reduces the incidence of preterm birth mother mortality, and miscarriage. Discussion: The expected impact of the proposed project includes reducing maternal and child mortality due to SCD and reducing the morbidity in pregnancy and delivery. Trial registration: This study was registered at ClinicalTrials.gov. Trial registration: NCT06417411, on May 16th, 2024.
- Foveation after spontaneous closure of an outer lamellar macular holePublication . Mendo, Inês; Camacho, Pedro; Carreira, Pedro; Cabral, DiogoVisual loss without relevant findings on examination often leads to multiple tests to distinguish true visual loss from malingering. Here, we used precise registration of MAIA microperimetry with spectral-domain optical coherence tomography (SD-OCT) to align retinal sensitivity data with anatomical tomographic indings in a patient with visual loss and normal clinical findings. This report followed the tenets of the Declaration of Helsinki. Summary statement: To evaluate retinal sensitivity in a patient with visual loss and normal clinical findings using a precise registration of microperimetry with spectral-domain optical coherence tomography.
- IA Generativa no ensino superior: perceções, crenças e desafios éticos dos estudantes de Psicologia e da EducaçãoPublication . Lopes, Carlos; Antunes, Maria Luz; Sanches, TatianaIntrodução: O impacto da Inteligência Artificial Generativa (IA-Gen) está a remodelar o ensino da psicologia e da educação. Este estudo explora as perceções de estudantes destas áreas do conhecimento sobre o uso de ferramentas de IA-Gen no apoio à aprendizagem, focando-se em três dimensões fundamentais: a) facilidade de uso e utilidade percebidas; b) personalização, interatividade e confiança; e c) inteligência percebida e intenção de adoção. Método: Foi adotado um delineamento quantitativo descritivo e uma análise qualitativa a duas questões abertas sobre a IA, envolvendo uma amostra de 272 estudantes (84,93% do género feminino; M = 19,78 anos, Med = 18 anos) a frequentar o primeiro ano de estudos universitários em três instituições de ensino superior portuguesas (Ispa-Instituto Universitário, Instituto de Educação da Universidade de Lisboa e FCSH da Universidade Nova de Lisboa). A amostra é predominantemente composta por estudantes das licenciaturas em Psicologia (73,2%) e Ciências da Educação (12,13%). Os participantes responderam a um questionário de 49 itens, elaborado especificamente pelos autores com base em instrumentos recentes de avaliação da adoção de IA-Gen (e.g., TAME-ChatGPT e a sua versão portuguesa da adoção do TAME-ChatGPT pela Universidade de Trás-os-Montes e Alto Douro [UTAD]). Resultados: Os resultados revelam que a IA-Gen é considerada uma tecnologia intuitiva e benéfica, com 68,9% dos estudantes a utilizá-la pelo menos semanalmente, sendo o ChatGPT (89%) a ferramenta dominante. As funções principais centram-se na compreensão de tópicos complexos (74,4%) e síntese de conteúdos (65,1%). Contudo, embora os estudantes se classifiquem maioritariamente como utilizadores de nível intermédio (65,4%), reconhecem que a eficácia depende da capacidade de formular boas perguntas (M=4,31). Persistem reservas significativas quanto à fiabilidade da ferramenta: a necessidade de validar a informação com fontes especialistas é quase unânime (M=4,64). Adicionalmente expressam-se preocupações com a erosão do pensamento crítico (M=3,94), o risco de plágio e a falta de segurança de dados (M=2,71). No plano macrossocial destaca-se uma consciência elevada sobre o impacto ambiental negativo da tecnologia (M=3,75). Discussão e Conclusões: Os estudantes manifestam uma postura de otimismo crítico, estando inclinados para a adoção tecnológica, mas conscientes das suas limitações éticas e cognitivas. A inteligência da IA é valorizada para funções explicativas, mas considerada inferior à dos docentes (M=2,44), sublinhando a importância da mediação humana. Estes resultados, contextualizados aos estudantes das áreas de Psicologia e Educação, ressaltam a urgência de estratégias de integração bem fundamentadas que alinhem o uso da IA-Gen com os princípios da Ciência Aberta, garantindo a transparência, a fiabilidade e o acesso livre a dados verificáveis. Diretrizes institucionais claras, o desenvolvimento profissional do corpo docente e iniciativas de formação em literacia em IA para estudantes são fundamentais para maximizar o potencial da IA-Gen e mitigar riscos como a dependência excessiva e a falta de originalidade académica.
- Language of flourishing: wellbeing literacy for motivation and emotion in higher educationPublication . Vital, Ana Paula; Lopes, Carlos; Vargas-Moniz, Maria João; Antunes, Maria LuzBackground: Wellbeing literacy, defined as the capability to comprehend and compose wellbeing language across contexts with intentionality, has emerged as a foundational capability for sustaining wellbeing, mental health, motivation, and academic success in higher education. Drawing on Oades’ five-component capability model - vocabulary and knowledge, multimodal comprehension, multimodal composition, context sensitivity, and intentionality—wellbeing literacy is considered a mediator between internal–external environments and students’ subjective wellbeing, resilience, and academic engagement. Objective: This scoping review maps how wellbeing literacy, including emergent forms such as digital wellbeing literacy and meliotropic mindsets, relates to motivation, emotion regulation, and flourishing among university students in diverse cultural and institutional settings. Method: Following PRISMA-ScR and JBI guidelines, a three-phase literature search was conducted from 2016 to 2025 in ERIC, PsycINFO, Scopus, PubMed, Web of Science, and SciELO, complemented by grey literature sources (e.g., ProQuest, OSF, RCAAP). Eligible studies focused on higher education students and conceptual or empirical work on wellbeing literacy and related literacies. Results: Higher wellbeing literacy consistently predicts greater life satisfaction, positive affect, and academic engagement, while relating to lower depression, anxiety, and stress. These associations are mediated by self-esteem and resilience. Evidence highlights pedagogy of belonging, multimodal communication, and salutogenic programs (e.g., laughter-based interventions) as promising contexts for cultivating relational and culturally responsive wellbeing literacy. Conclusion: Wellbeing literacy acts as a systemic lever for proactive, capability-focused approaches to student motivation and emotion. It supports the shift from deficit-based mental health responses to a whole-university, context-sensitive “languages of flourishing".
- Implementing evidence-based infection prevention strategies in primary school environmentsPublication . Pena, Pedro; Cervantes, Renata; Viegas, CarlaWhy schools? High-contact settings where respiratory pathogens spread rapidly - young children have developing immune systems and limited hygiene autonomy. Critical Gap: no standardised, evidence-based IPC protocols tailored to school operational assistants - cleaning and support staff who are frontline but often overlooked. InChildHealthProject - This study is a spin-off of a European research project, “Identifying determinants for indoor air quality and their health impact in environments for children: measures to improve indoor air quality and reduce disease burdens”.
- Fungal resistance and public health implications: the use of wastewater treatment plant (WWTP) sludge in agriculturePublication . Pimenta, Márcia; Cervantes, Renata; Pena, Pedro; Sabino, Raquel; Viegas, CarlaThis study aimed to assess microbial and fungal risks of commercial fertilizers and substrates associated with waste-derived materials in Portugal, integrating antifungal resistance screening under a One Health framework.
- A picture of health? Microorganisms in Portuguese colour photograph collections and related occupational environmentsPublication . Fernandes, Lénia Oliveira; Cervantes, Renata; Pena, Pedro; Sá, Susana França de; Tavares, Emília; Roldão, Élia; Viegas, CarlaMicrobiological degradation is an issue affecting colour photograph collections, also potentially hazardous to those working with these collections, especially in the long term. After collection surveys, the photographs and occupational environments of three institutions in Portugal were assessed for comparison. This study aimed to characterise microorganisms causing deterioration of collections and their associated environments, and to assess potential health implications for cultural heritage professionals.
- «
- 1 (current)
- 2
- 3
- »