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Blood molecular profile to predict genotoxicity from exposure to antineoplastic drugs: a comparison with cytokinesis-block micronucleus assay results

2023-05Conference poster Open access
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datacite.subject.sdg03:Saúde de Qualidade
dc.contributor.authorLadeira, Carina
dc.contributor.authorAraújo, Rúben
dc.contributor.authorRamalhete, Luís
dc.contributor.authorTeixeira, Hélder
dc.contributor.authorCalado, Cecília R. C.
dc.date.accessioned2025-08-29T10:29:39Z
dc.date.available2025-08-29T10:29:39Z
dc.date.issued2023-05
dc.descriptionThis work was supported by Instituto Politécnico de Lisboa under grant IDI&CA/IPL/ 2017 GenTox ESTeSL and by Fundação para a Ciência e a Tecnologia, Portugal, under grant DSAIPA/DS/ 0117 2020. The human biomonitoring had financial support given by the Portuguese Authority of Working Conditions (Project reference 036 APJ/09).
dc.description.abstractGenotoxicity is an important information that should be included in human biomonitoring programs design. Cytogenetic methods are usually laborious and time-consuming; therefore, the development of new molecular methods is an added value. This study aimed to evaluate if the molecular profile of previously frozen whole blood acquired by Fourier Transform Infrared (FTIR) spectroscopy allows for to assessment of genotoxicity in occupational exposure to antineoplastic drugs in hospital professionals, as obtained by the lymphocyte cytokinesis block micronucleus (CBMN) assay.eng
dc.identifier.citationLadeira C, Araújo R, Ramalhete L, Teixeira H, Calado CR. Blood molecular profile to predict genotoxicity from exposure to antineoplastic drugs: a comparison with cytokinesis-block micronucleus assay results. In: 51st European Environmental Mutagenesis and Genomics Society (EEMGS) & 27th Spanish Environmental Mutagenesis and Genomics Society (SEMA), Málaga (Spain), May 15-18, 2023.
dc.identifier.urihttp://hdl.handle.net/10400.21/22057
dc.language.isoeng
dc.peerreviewedyes
dc.publisherSpringer International Publishing
dc.relation.ispartofGlobal Perspectives on Children's Health Literacy
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectMolecular profile
dc.subjectFTIR-spectroscopy
dc.subjectGenotoxicity
dc.subjectCytokinesis-blocked micronucleus assay
dc.subjectFrozen blood
dc.subjectAntineoplastics
dc.subjectIDI&CA/IPL/2017/GenTox/ESTeSL
dc.subjectFCT_DSAIPA/DS/0117/2020
dc.subjectACT_036APJ/09
dc.titleBlood molecular profile to predict genotoxicity from exposure to antineoplastic drugs: a comparison with cytokinesis-block micronucleus assay resultseng
dc.typeconference poster
dspace.entity.typePublication
oaire.citation.conferenceDate2023-05
oaire.citation.conferencePlaceMálaga, Espanha
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameLadeira
person.givenNameCarina
person.identifier144237
person.identifier.ciencia-id801C-1BBA-1D9E
person.identifier.orcid0000-0001-5588-0074
person.identifier.ridJ-2572-2012
person.identifier.scopus-author-id36463788000
relation.isAuthorOfPublication1aef4b60-4197-436b-84ab-80d31cbaed33
relation.isAuthorOfPublication.latestForDiscovery1aef4b60-4197-436b-84ab-80d31cbaed33

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