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Advisor(s)
Abstract(s)
Systemic-opportunistic fungal infections caused by azole-resistant fungi, including Aspergillus fumigatus, are emerging as an important cause of human disease with high associated morbimortality rates worldwide. The resistance to the limited arsenal of antifungal drugs is a serious concern, making it imperative to assess new compounds with antimicrobial properties and no cytotoxic effects, to be utilized as adjuvants in fungal therapy. Epigallocatechin-3-gallate (EGCG), the largest constituent of green tea, has demonstrated anti-infective properties in several in vitro studies however, information regarding EGCG antimycotic activity and synergistic interactions between EGCG and triazoles against A. fumigatus is scarce. This work aimed to assess the antimycotic potential of EGCG against azole-resistant isolates of A. fumigatus, and the potential synergistic effects between EGCG and commonly used triazole antifungal drugs, namely itraconazole (ITR), voriconazole (VOR), and posaconazole (POS).
Description
Project "Resistant mycobiota and mycotoxigenic profile of tea and medicinal plants” (IPL/2020/TEAResMyc_ESTeSL)
Keywords
Occupational health Occupational exposure Azole-resistance Epigallocatechin-3-gallate IPL/2020/TEAResMyc_ESTeSL
Citation
Ponte TS, Ribeiro E, Caetano LA. Epigallocathecahin-3-gallate antimycotic and azole resistant modulator potential against triazole-resistant aspergillus fumigatus. In: Natural products application: health, cosmetic and food (online edition), Instituto Politécnico de Bragança, February 4-5, 2021.