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Epigallocathecahin-3-gallate antimycotic and azole resistant modulator potential against triazole-resistant aspergillus fumigatus

2021-02Conference object Open access
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dc.contributor.authorPonte, Tomás Saraiva
dc.contributor.authorRibeiro, Edna
dc.contributor.authorCaetano, Liliana Aranha
dc.date.accessioned2021-02-10T19:38:45Z
dc.date.available2021-02-10T19:38:45Z
dc.date.issued2021-02
dc.descriptionProject "Resistant mycobiota and mycotoxigenic profile of tea and medicinal plants” (IPL/2020/TEAResMyc_ESTeSL)pt_PT
dc.description.abstractSystemic-opportunistic fungal infections caused by azole-resistant fungi, including Aspergillus fumigatus, are emerging as an important cause of human disease with high associated morbimortality rates worldwide. The resistance to the limited arsenal of antifungal drugs is a serious concern, making it imperative to assess new compounds with antimicrobial properties and no cytotoxic effects, to be utilized as adjuvants in fungal therapy. Epigallocatechin-3-gallate (EGCG), the largest constituent of green tea, has demonstrated anti-infective properties in several in vitro studies however, information regarding EGCG antimycotic activity and synergistic interactions between EGCG and triazoles against A. fumigatus is scarce. This work aimed to assess the antimycotic potential of EGCG against azole-resistant isolates of A. fumigatus, and the potential synergistic effects between EGCG and commonly used triazole antifungal drugs, namely itraconazole (ITR), voriconazole (VOR), and posaconazole (POS).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationPonte TS, Ribeiro E, Caetano LA. Epigallocathecahin-3-gallate antimycotic and azole resistant modulator potential against triazole-resistant aspergillus fumigatus. In: Natural products application: health, cosmetic and food (online edition), Instituto Politécnico de Bragança, February 4-5, 2021.pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/12812
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relationProject "Resistant mycobiota and mycotoxigenic profile of tea and medicinal plants” (IPL/2020/TEAResMyc_ESTeSL)pt_PT
dc.relation.publisherversionhttp://esa.ipb.pt/naturalproducts/pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectOccupational healthpt_PT
dc.subjectOccupational exposurept_PT
dc.subjectAzole-resistancept_PT
dc.subjectEpigallocatechin-3-gallatept_PT
dc.subjectIPL/2020/TEAResMyc_ESTeSLpt_PT
dc.titleEpigallocathecahin-3-gallate antimycotic and azole resistant modulator potential against triazole-resistant aspergillus fumigatuspt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.citation.conferencePlaceBragançapt_PT
person.familyNameRibeiro
person.familyNameAranha Caetano
person.givenNameEdna
person.givenNameLiliana
person.identifier.ciencia-idC414-CDF2-D35A
person.identifier.ciencia-id9716-9DAC-532A
person.identifier.orcid0000-0003-1316-7750
person.identifier.orcid0000-0003-1496-2609
rcaap.rightsopenAccesspt_PT
rcaap.typeconferenceObjectpt_PT
relation.isAuthorOfPublicationa571bf34-bcda-49ca-b5cb-4cdecbb3d9c7
relation.isAuthorOfPublication6517c656-f913-4f54-8682-77c2856c9e4c
relation.isAuthorOfPublication.latestForDiscoverya571bf34-bcda-49ca-b5cb-4cdecbb3d9c7

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