Evaluating the impact of using natural fixative agents as alternatives to formaldehyde in histopathology: a systematic review

Horta, Andreia; Condesso, Nádia; Maia-Matos, Mário; Borges-Ferro, A

http://hdl.handle.net/10400.21/22401

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Abstract(s)

The histological technique involves several steps to prepare tissues for microscopic analysis, with fixation being one of the key steps. Formaldehyde is the most used fixing agent; however, it poses significant health risks and is classified as a Group 1 human carcinogen by the IARC and the NTP. This concern has prompted the search for safer alternatives. This study aims to identify a less harmful natural substitute for formaldehyde that can reduce or eliminate exposure to this hazardous reagent. To achieve this objective, a systematic review explored the potential of natural fixatives that can perform similar functions with lower toxicity.

Keywords

Histopathology Formaldehyde Natural fixative agents Toxicity Systematic review

URI

http://hdl.handle.net/10400.21/22401

Citation

Horta A, Condesso N, Maia-Matos M, Borges-Ferro A. Evaluating the impact of using natural fixative agents as alternatives to formaldehyde in histopathology: a systematic review. In: III Congresso Nacional da BioMedLab, Auditório Prof. Armando Simões dos Santos, Faculdade de Medicina Dentária, Universidade de Lisboa, 7 a 9 de março de 2025.