Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.21/3934
Título: Molecular epidemiology of Aspergillus collected from cystic fibrosis patients
Autor: Sabino, Raquel
Ferreira, Jose A.G.
Moss, Richard B.
Valente, Joana
Veríssimo, Cristina
Carolino, Elisabete
Clemons, Karl V.
Everson, Cassie
Banaei, Niaz
Penner, John
Stevens, David A.
Palavras-chave: Cystic fibrosis
Cryptic species
Chronic illness
Chronic lung infection
A. fumigatus
Data: Jul-2015
Editora: Elsevier
Citação: Sabino R, Ferreira JA, Moss RB, Valente J, Veríssimo C, Carolino E, et al. Molecular epidemiology of Aspergillus collected from cystic fibrosis patients. J Cyst Fibros. 2015;14(4):474-81.
Resumo: Background - Aspergillus respiratory infection is a common complication in cystic fibrosis (CF) and is associated with loss of pulmonary function and allergic disease. Methods - Fifty-three Aspergillus isolates recovered from CF patients were identified to species by Internal Transcribed Spacer Region (ITS), β-tubulin, and calmodulin sequencing. Results - Three species complexes (Terrei, Nigri, and Fumigati) were found. Identification to species level gave a single Aspergillus terreus sensu stricto, one Aspergillus niger sensu stricto and 51 Aspergillus fumigatus sensu stricto isolates. No cryptic species were found. Conclusions - To our knowledge, this is the first prospective study of Aspergillus species in CF using molecular methods. The paucity of non-A. fumigatus and of cryptic species of A. fumigatus suggests a special association of A. fumigatus sensu stricto with CF airways, indicating it likely displays unique characteristics making it suitable for chronic residence in that milieu. These findings could refine an epidemiologic and therapeutic approach geared to this pathogen.
Peer review: yes
URI: http://hdl.handle.net/10400.21/3934
DOI: 10.1016/j.jcf.2014.10.005
Versão do Editor: http://www.sciencedirect.com/science/article/pii/S156919931400232X
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