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Molecular epidemiology of Aspergillus collected from cystic fibrosis patients

2015-07Journal article Restricted access
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dc.contributor.authorSabino, Raquel
dc.contributor.authorFerreira, Jose A.G.
dc.contributor.authorMoss, Richard B.
dc.contributor.authorValente, Joana
dc.contributor.authorVeríssimo, Cristina
dc.contributor.authorCarolino, Elisabete
dc.contributor.authorClemons, Karl V.
dc.contributor.authorEverson, Cassie
dc.contributor.authorBanaei, Niaz
dc.contributor.authorPenner, John
dc.contributor.authorStevens, David A.
dc.date2015
dc.date.accessioned2014-11-13T10:53:25Z
dc.date.available2014-11-13T10:53:25Z
dc.date.issued2015-07
dc.description.abstractBackground - Aspergillus respiratory infection is a common complication in cystic fibrosis (CF) and is associated with loss of pulmonary function and allergic disease. Methods - Fifty-three Aspergillus isolates recovered from CF patients were identified to species by Internal Transcribed Spacer Region (ITS), β-tubulin, and calmodulin sequencing. Results - Three species complexes (Terrei, Nigri, and Fumigati) were found. Identification to species level gave a single Aspergillus terreus sensu stricto, one Aspergillus niger sensu stricto and 51 Aspergillus fumigatus sensu stricto isolates. No cryptic species were found. Conclusions - To our knowledge, this is the first prospective study of Aspergillus species in CF using molecular methods. The paucity of non-A. fumigatus and of cryptic species of A. fumigatus suggests a special association of A. fumigatus sensu stricto with CF airways, indicating it likely displays unique characteristics making it suitable for chronic residence in that milieu. These findings could refine an epidemiologic and therapeutic approach geared to this pathogen.por
dc.identifier.citationSabino R, Ferreira JA, Moss RB, Valente J, Veríssimo C, Carolino E, et al. Molecular epidemiology of Aspergillus collected from cystic fibrosis patients. J Cyst Fibros. 2015;14(4):474-81.por
dc.identifier.doi10.1016/j.jcf.2014.10.005
dc.identifier.urihttp://hdl.handle.net/10400.21/3934
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherElsevierpor
dc.relation.publisherversionhttp://www.sciencedirect.com/science/article/pii/S156919931400232Xpor
dc.subjectCystic fibrosispor
dc.subjectAspergilluspor
dc.subjectCryptic speciespor
dc.subjectChronic illnesspor
dc.subjectChronic lung infectionpor
dc.subjectA. fumigatuspor
dc.titleMolecular epidemiology of Aspergillus collected from cystic fibrosis patientspor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage481
oaire.citation.startPage474
oaire.citation.titleJournal of Cystic Fibrosispor
oaire.citation.volume14
person.familyNameSabino
person.familyNameCarolino
person.givenNameRaquel Filipa Pinheiro
person.givenNameElisabete
person.identifier.ciencia-id1216-EFA3-1E0F
person.identifier.orcid0000-0001-6585-7775
person.identifier.orcid0000-0003-4165-7052
person.identifier.ridF-1012-2015
person.identifier.scopus-author-id35796067600
person.identifier.scopus-author-id25821697000
rcaap.rightsrestrictedAccesspor
rcaap.typearticlepor
relation.isAuthorOfPublicationcf64684a-fb92-4421-91da-14fb15462fad
relation.isAuthorOfPublication77930d39-ed34-44dc-a4a6-9bf833e5e688
relation.isAuthorOfPublication.latestForDiscoverycf64684a-fb92-4421-91da-14fb15462fad

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