Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.21/3726
Título: Assessment of genotoxic effects in nurses handling cytostatic drugs
Autor: Ladeira, Carina
Viegas, Susana
Pádua, Mário
Gomes, Mário
Carolino, Elisabete
Gomes, M. C.
Brito, Miguel
Palavras-chave: Environmental health
Surface contamination
Cytostatic drugs
Data: Jul-2014
Editora: Taylor & Francis
Citação: Ladeira C, Viegas S, Pádua M, Gomes M, Carolino E, Gomes MC, Brito M. Assessment of genotoxic effects in nurses handling cytostatic drugs. J Toxicol Environ Health A. 2014;77(14-16):879-87.
Resumo: Several antineoplastic drugs have been classified as carcinogens by the International Agency for Research on Cancer (IARC) on the basis of epidemiological findings, animal carcinogenicity data, and outcomes of in vitro genotoxicity studies. 5-Fluorouracil (5-FU), which is easily absorbed through the skin, is the most frequently used antineoplastic agent in Portuguese hospitals and therefore may be used as an indicator of surface contamination. The aims of the present investigation were to (1) examine surface contamination by 5-FU and (2) assess the genotoxic risk using cytokinesis-block micronucleus assay in nurses from two Portuguese hospitals. The study consisted of 2 groups: 27 nurses occupationally exposed to cytostatic agents (cases) and 111 unexposed individuals (controls). Peripheral blood lymphocytes (PBL) were collected in order to measure micronuclei (MN) in both groups. Hospital B showed a higher numerical level of contamination but not significantly different from Hospital A. However; Hospital A presented the highest value of contamination and also a higher proportion of contaminated samples. The mean frequency of MN was significantly higher in exposed workers compared with controls. No significant differences were found among MN levels between the two hospitals. The analysis of confounding factors showed that age is a significant variable in MN frequency occurrence. Data suggest that there is a potential genotoxic damage related to occupational exposure to cytostatic drugs in oncology nurses.
Peer review: yes
URI: http://hdl.handle.net/10400.21/3726
DOI: 10.1080/15287394.2014.910158
Versão do Editor: http://www.tandfonline.com/doi/full/10.1080/15287394.2014.910158#.U-DqfLGG7qE
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