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Assessment of genotoxic effects in nurses handling cytostatic drugs

2014-07Journal article Restricted access
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dc.contributor.authorLadeira, Carina
dc.contributor.authorViegas, Susana
dc.contributor.authorPádua, Mário
dc.contributor.authorGomes, Mário
dc.contributor.authorCarolino, Elisabete
dc.contributor.authorGomes, M. C.
dc.contributor.authorBrito, Miguel
dc.date.accessioned2014-08-05T14:40:15Z
dc.date.available2014-08-05T14:40:15Z
dc.date.issued2014-07
dc.description.abstractSeveral antineoplastic drugs have been classified as carcinogens by the International Agency for Research on Cancer (IARC) on the basis of epidemiological findings, animal carcinogenicity data, and outcomes of in vitro genotoxicity studies. 5-Fluorouracil (5-FU), which is easily absorbed through the skin, is the most frequently used antineoplastic agent in Portuguese hospitals and therefore may be used as an indicator of surface contamination. The aims of the present investigation were to (1) examine surface contamination by 5-FU and (2) assess the genotoxic risk using cytokinesis-block micronucleus assay in nurses from two Portuguese hospitals. The study consisted of 2 groups: 27 nurses occupationally exposed to cytostatic agents (cases) and 111 unexposed individuals (controls). Peripheral blood lymphocytes (PBL) were collected in order to measure micronuclei (MN) in both groups. Hospital B showed a higher numerical level of contamination but not significantly different from Hospital A. However; Hospital A presented the highest value of contamination and also a higher proportion of contaminated samples. The mean frequency of MN was significantly higher in exposed workers compared with controls. No significant differences were found among MN levels between the two hospitals. The analysis of confounding factors showed that age is a significant variable in MN frequency occurrence. Data suggest that there is a potential genotoxic damage related to occupational exposure to cytostatic drugs in oncology nurses.por
dc.identifier.citationLadeira C, Viegas S, Pádua M, Gomes M, Carolino E, Gomes MC, Brito M. Assessment of genotoxic effects in nurses handling cytostatic drugs. J Toxicol Environ Health A. 2014;77(14-16):879-87.por
dc.identifier.doi10.1080/15287394.2014.910158
dc.identifier.urihttp://hdl.handle.net/10400.21/3726
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherTaylor & Francispor
dc.relation.publisherversionhttp://www.tandfonline.com/doi/full/10.1080/15287394.2014.910158#.U-DqfLGG7qEpor
dc.subjectEnvironmental healthpor
dc.subjectGenotoxicitypor
dc.subjectSurface contaminationpor
dc.subjectCarcinogenicitypor
dc.subjectHospitalpor
dc.subjectNursingpor
dc.subjectCytostatic drugspor
dc.titleAssessment of genotoxic effects in nurses handling cytostatic drugspor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage887por
oaire.citation.startPage879por
oaire.citation.titleJournal of Toxicology and Environmental Health. Part Apor
oaire.citation.volume77por
person.familyNameLadeira
person.familyNameViegas
person.familyNameCarolino
person.familyNameBrito
person.givenNameCarina
person.givenNameSusana
person.givenNameElisabete
person.givenNameMiguel
person.identifier144237
person.identifier248817
person.identifier.ciencia-id801C-1BBA-1D9E
person.identifier.ciencia-idA919-7318-63DC
person.identifier.ciencia-id1216-EFA3-1E0F
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person.identifier.orcid0000-0001-5588-0074
person.identifier.orcid0000-0003-1015-8760
person.identifier.orcid0000-0003-4165-7052
person.identifier.orcid0000-0001-6394-658X
person.identifier.ridJ-2572-2012
person.identifier.ridI-4053-2012
person.identifier.ridF-1012-2015
person.identifier.ridA-7970-2016
person.identifier.scopus-author-id36463788000
person.identifier.scopus-author-id35270591500
person.identifier.scopus-author-id25821697000
person.identifier.scopus-author-id35224551000
rcaap.rightsrestrictedAccesspor
rcaap.typearticlepor
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