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The comet assay as a tool in human biomonitoring studies of environmental and occupational exposure to chemicals: a systematic scoping review

2024-04Journal article Open access
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dc.contributor.authorLadeira, Carina
dc.contributor.authorMøller, Peter
dc.contributor.authorGiovannelli, Lisa
dc.contributor.authorGajski, Goran
dc.contributor.authorHaveric, Anja
dc.contributor.authorBankoglu, Ezgi Eyluel
dc.contributor.authorAzqueta, Amaya
dc.contributor.authorGerić, Marko
dc.contributor.authorStopper, Helga
dc.contributor.authorCabêda, José
dc.contributor.authorTonin, Fernanda
dc.contributor.authorCollins, Andrew
dc.date.accessioned2024-04-11T11:58:18Z
dc.date.available2024-04-11T11:58:18Z
dc.date.issued2024-04
dc.descriptionThis work was supported by the affiliated institutions, European Regional Development Fund project KK.01.1.1.02.0007 (Rec-IMI), the Croatian Science Foundation (HUMNap project #1192), the Horizon Europe (EDIAQI project #101057497), the European Union—Next Generation EU 533-03-23-0006 (BioMolTox), and the International Comet Assay Working Group (ICAWG).pt_PT
dc.description.abstractBiomonitoring of human populations exposed to chemical substances that can act as potential mutagens or carcinogens may enable the detection of damage and early disease prevention. In recent years, the comet assay has become an important tool for assessing DNA damage, both in environmental and occupational exposure contexts. To evidence the role of the comet assay in human biomonitoring, we have analysed original research studies of environmental or occupational exposure that used the comet assay in their assessments, following the PRISMA-ScR method (preferred reporting items for systematic reviews and meta-analyses extension for scoping reviews). Groups of chemicals were designated according to a broad classification, and the results obtained from over 300 original studies (n = 123 on air pollutants, n = 14 on anaesthetics, n = 18 on antineoplastic drugs, n = 57 on heavy metals, n = 59 on pesticides, and n = 49 on solvents) showed overall higher values of DNA strand breaks in the exposed subjects in comparison with the unexposed. In summary, our systematic scoping review strengthens the relevance of the use of the comet assay in assessing DNA damage in human biomonitoring studies.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationLadeira C, Møller P, Giovannelli L, Gajski G, Haveric A, Bankoglu EE, et al. The comet assay as a tool in human biomonitoring studies of environmental and occupational exposure to chemicals: a systematic scoping review. Toxics. 2024;12(4):270.pt_PT
dc.identifier.doi10.3390/toxics12040270pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/17298
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationEuropean Regional Development Fund project KK.01.1.1.02.0007 (Rec-IMI)pt_PT
dc.relationHorizon Europe (EDIAQI project #101057497)pt_PT
dc.relationEuropean Union - Next Generation EU 533-03-23-0006 (BioMolTox)pt_PT
dc.relation.publisherversionhttps://www.mdpi.com/2305-6304/12/4/270pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectComet assaypt_PT
dc.subjectHuman biomonitoringpt_PT
dc.subjectAir pollutionpt_PT
dc.subjectAnestheticspt_PT
dc.subjectAntineoplastic drugspt_PT
dc.subjectHeavy metalspt_PT
dc.subjectPesticidespt_PT
dc.subjectSolventspt_PT
dc.subjectExposurept_PT
dc.subjectERDF KK.01.1.1.02.0007 (Rec-IMI)pt_PT
dc.subjectEDIAQI project #101057497pt_PT
dc.subjectNext Generation EU 533-03-23-0006 (BioMolTox)pt_PT
dc.titleThe comet assay as a tool in human biomonitoring studies of environmental and occupational exposure to chemicals: a systematic scoping reviewpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue4pt_PT
oaire.citation.startPage270pt_PT
oaire.citation.titleToxicspt_PT
oaire.citation.volume12pt_PT
person.familyNameLadeira
person.familyNameTonin
person.givenNameCarina
person.givenNameFernanda
person.identifier144237
person.identifier.ciencia-id801C-1BBA-1D9E
person.identifier.ciencia-idD01C-C700-9411
person.identifier.orcid0000-0001-5588-0074
person.identifier.orcid0000-0003-4262-8608
person.identifier.ridJ-2572-2012
person.identifier.ridO-2050-2017
person.identifier.scopus-author-id36463788000
person.identifier.scopus-author-id56085115800
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication1aef4b60-4197-436b-84ab-80d31cbaed33
relation.isAuthorOfPublication61ded30e-ecec-4b3e-b953-2293e080ebdd
relation.isAuthorOfPublication.latestForDiscovery1aef4b60-4197-436b-84ab-80d31cbaed33

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