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Orientador(es)
Resumo(s)
Biomonitoring of human populations exposed to chemical substances that can act as potential mutagens or carcinogens may enable the detection of damage and early disease prevention. In recent years, the comet assay has become an important tool for assessing DNA damage, both in environmental and occupational exposure contexts. To evidence the role of the comet assay in human biomonitoring, we have analysed original research studies of environmental or occupational exposure that used the comet assay in their assessments, following the PRISMA-ScR method (preferred reporting items for systematic reviews and meta-analyses extension for scoping reviews). Groups of chemicals were designated according to a broad classification, and the results obtained from over 300 original studies (n = 123 on air pollutants, n = 14 on anaesthetics, n = 18 on antineoplastic drugs, n = 57 on heavy metals, n = 59 on pesticides, and n = 49 on solvents) showed overall higher values of DNA strand breaks in the exposed subjects in comparison with the unexposed. In summary, our systematic scoping review strengthens the relevance of the use of the comet assay in assessing DNA damage in human biomonitoring studies.
Descrição
This work was supported by the affiliated institutions, European Regional Development Fund project KK.01.1.1.02.0007 (Rec-IMI), the Croatian Science Foundation (HUMNap project #1192), the Horizon Europe (EDIAQI project #101057497), the European Union—Next Generation EU 533-03-23-0006 (BioMolTox), and the International Comet Assay Working Group (ICAWG).
Palavras-chave
Comet assay Human biomonitoring Air pollution Anesthetics Antineoplastic drugs Heavy metals Pesticides Solvents Exposure ERDF KK.01.1.1.02.0007 (Rec-IMI) EDIAQI project #101057497 Next Generation EU 533-03-23-0006 (BioMolTox)
Contexto Educativo
Citação
Ladeira C, Møller P, Giovannelli L, Gajski G, Haveric A, Bankoglu EE, et al. The comet assay as a tool in human biomonitoring studies of environmental and occupational exposure to chemicals: a systematic scoping review. Toxics. 2024;12(4):270.
Editora
MDPI