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Advisor(s)
Abstract(s)
Endocrine disrupting chemicals (EDCs) are exogenous agents commonly employed in a wide variety of consumer products and indoor/outdoor applications. Human exposure to these compounds either by environmental and/or occupational sources is omnipresent, persistent and occurs in complex mixtures which, therefore, can origin a mixed “body burden” of contaminants. Extensive research in human cell lines, particularly from sex hormone-responsive tissues, show that EDCs can simultaneously and differentially trigger specific signaling pathways, predominantly associated to estrogen receptors. Evidence demonstrates that EDCs endorse distinct cellular responses in different cell lines, however, most of the studies have focused exclusively in the independent action of the tested compounds whereas information regarding EDCs mixtures effects is still scared. We performed a revision of the state of the art in PubMed focused on studies that evaluate EDCs mixture effects. Based on published data a review of the utilized EDCs, tested doses, studied cell lines and observed effects of co-exposure studies are presented. Although the independent action of chemicals is still considered the main principle of EDCs mixture toxicity, the evidence demonstrates that some effects cannot be predicted when analyzing single compounds independently and thus it is undoubtedly that the daily doses of each compound are not the only one that can be taken into consideration. There is an emergent concern that the current toxicological assessment based in a chemical-by-chemical approach may not be adequately protected in the context of EDCs mixtures and that recognizing potential aggregate and cumulative exposures are crucial for an adequate risk assessment.
Description
Keywords
Endocrine disrupting chemicals Mixtures Biomonitoring Windows of exposure Risk assessment
Pedagogical Context
Citation
Ribeiro-Varandas E, Ladeira C, Viegas S. EDCs mixture effects in human cell lines. In: EUROTOX – 52nd Congress of the European Societies of Toxicology, FIBES Congress Center, Seville (Spain), September 4-7, 2016. Toxicol Lett. 2016;258 Suppl:S320.
Publisher
Elsevier