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EDCs mixture effects in human cell lines

2016-09Documento de conferência Acesso aberto
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dc.contributor.authorRibeiro, Edna
dc.contributor.authorLadeira, Carina
dc.contributor.authorViegas, Susana
dc.date.accessioned2017-12-07T17:46:22Z
dc.date.available2017-12-07T17:46:22Z
dc.date.issued2016-09
dc.description.abstractEndocrine disrupting chemicals (EDCs) are exogenous agents commonly employed in a wide variety of consumer products and indoor/outdoor applications. Human exposure to these compounds either by environmental and/or occupational sources is omnipresent, persistent and occurs in complex mixtures which, therefore, can origin a mixed “body burden” of contaminants. Extensive research in human cell lines, particularly from sex hormone-responsive tissues, show that EDCs can simultaneously and differentially trigger specific signaling pathways, predominantly associated to estrogen receptors. Evidence demonstrates that EDCs endorse distinct cellular responses in different cell lines, however, most of the studies have focused exclusively in the independent action of the tested compounds whereas information regarding EDCs mixtures effects is still scared. We performed a revision of the state of the art in PubMed focused on studies that evaluate EDCs mixture effects. Based on published data a review of the utilized EDCs, tested doses, studied cell lines and observed effects of co-exposure studies are presented. Although the independent action of chemicals is still considered the main principle of EDCs mixture toxicity, the evidence demonstrates that some effects cannot be predicted when analyzing single compounds independently and thus it is undoubtedly that the daily doses of each compound are not the only one that can be taken into consideration. There is an emergent concern that the current toxicological assessment based in a chemical-by-chemical approach may not be adequately protected in the context of EDCs mixtures and that recognizing potential aggregate and cumulative exposures are crucial for an adequate risk assessment.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationRibeiro-Varandas E, Ladeira C, Viegas S. EDCs mixture effects in human cell lines. In: EUROTOX – 52nd Congress of the European Societies of Toxicology, FIBES Congress Center, Seville (Spain), September 4-7, 2016. Toxicol Lett. 2016;258 Suppl:S320.pt_PT
dc.identifier.doi10.1016/j.toxlet.2016.06.2090pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/7676
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relation.publisherversionhttp://www.sciencedirect.com/science/article/pii/S0378427416322391pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectEndocrine disrupting chemicalspt_PT
dc.subjectMixturespt_PT
dc.subjectBiomonitoringpt_PT
dc.subjectWindows of exposurept_PT
dc.subjectRisk assessmentpt_PT
dc.titleEDCs mixture effects in human cell linespt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.citation.endPageS320pt_PT
oaire.citation.issueSupplpt_PT
oaire.citation.startPageS320pt_PT
oaire.citation.titleToxicology Letterspt_PT
oaire.citation.volume258pt_PT
person.familyNameRibeiro
person.familyNameLadeira
person.familyNameViegas
person.givenNameEdna
person.givenNameCarina
person.givenNameSusana
person.identifier144237
person.identifier248817
person.identifier.ciencia-idC414-CDF2-D35A
person.identifier.ciencia-id801C-1BBA-1D9E
person.identifier.ciencia-idA919-7318-63DC
person.identifier.orcid0000-0003-1316-7750
person.identifier.orcid0000-0001-5588-0074
person.identifier.orcid0000-0003-1015-8760
person.identifier.ridJ-2572-2012
person.identifier.ridI-4053-2012
person.identifier.scopus-author-id36463788000
person.identifier.scopus-author-id35270591500
rcaap.rightsopenAccesspt_PT
rcaap.typeconferenceObjectpt_PT
relation.isAuthorOfPublicationa571bf34-bcda-49ca-b5cb-4cdecbb3d9c7
relation.isAuthorOfPublication1aef4b60-4197-436b-84ab-80d31cbaed33
relation.isAuthorOfPublication13115332-43f7-4048-a8a5-2f2b855a8c92
relation.isAuthorOfPublication.latestForDiscovery13115332-43f7-4048-a8a5-2f2b855a8c92

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