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Distribution of CCR5-Delta32, CCR2-64I, and SDF1-3’A host genetic factors in HIV-infected and uninfected individuals in Luanda, Angola

2025-05Journal article Open access
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datacite.subject.sdg03:Saúde de Qualidade
dc.contributor.authorSebastião, Cruz S.
dc.contributor.authorPimentel, Victor
dc.contributor.authorJandondo, Domingos
dc.contributor.authorSebastião, Joana M. K.
dc.contributor.authorSacomboio, Euclides
dc.contributor.authorPingarilho, Marta
dc.contributor.authorBrito, Miguel
dc.contributor.authorCassinela, Edson kuatelela
dc.contributor.authorVasconcelos, Jocelyne Neto de
dc.contributor.authorAbecasis, Ana B.
dc.contributor.authorMorais, Joana
dc.date.accessioned2025-06-05T10:34:01Z
dc.date.available2025-06-05T10:34:01Z
dc.date.issued2025-05
dc.descriptionThis research was funded by the Fundação Calouste Gulbenkian (FCG), under the ENVOLVE Ciência PALOP program that funded the HITOLA project (Number 250466), FCT MARVEL (PTDC/SAU-PUB/4018/2021), FCT GHTMUID/04413/2020, and LA-REAL-LA/P/0117/2020.
dc.description.abstractBackground: The HIV/AIDS pandemic remains a public health concern. Studies on host genetic polymorphisms that confer resistance to HIV-1 infection or delay HIV disease progression are scarce in African countries. Herein, we investigate the proportion of the mutated phenotype of the AIDS-related polymorphisms CCR5-Delta32, CCR2-64I, and SDF1-3'A in HIV-infected and uninfected individuals in Luanda, the capital of Angola, a sub-Saharan African country. Methods: This was a cross-sectional study conducted with 284 individuals, of whom 159 were HIV-negative and 125 were HIV-positive. The CCR5-Delta32, CCR2-64I, and SDF1-3'A genotypes were detected by conventional PCR and visualised on a 2% agarose gel. A Chi-square test determined the frequency of each genetic variant and was deemed significant when p < 0.05. Results: The frequency of CCR5-Delta32, CCR2-64I, and SDF1-3 A was 0% (0/272), 60.2% (154/256), and 42.5% (114/268), respectively. CCR2-64I and SDF1-3 A polymorphisms were statistically related to HIV infection (p < 0.001). Statistically significant was observed between ABO blood groups (p = 0.006) and HIV-1 subtype (p = 0.015) with CCR2-64I. Also, the age group (p = 0.024) and RH blood group (p = 0.018) were statistically related to the distribution of SDF1-3 A polymorphism. Conclusions: We found no CCR5-Delta32 allele, while CCR2-64I and SDF1-3'A were found and presented a relationship with HIV infection, age, ABO/RH blood group, and HIV-1 subtypes. The observed associations of CCR2-64I and SDF1-3'A with HIV underscore the urgent need for further multidisciplinary research, with potential implications for targeted prevention and public health strategies. Therefore, studies investigating biological and non-biological factors related to susceptibility to HIV infection and AIDS progression or death should be conducted in Angola.eng
dc.identifier.citationSebastião CS, Pimentel V, Jandondo D, Sebastião JM, Sacomboio E, Brito M, et al. Distribution of CCR5-Delta32, CCR2-64I, and SDF1-3'A host genetic factors in HIV-infected and uninfected individuals in Luanda, Angola. AIDS Res Ther. 2025;22(1):54.
dc.identifier.doi10.1186/s12981-025-00751-7
dc.identifier.issn1742-6405
dc.identifier.urihttp://hdl.handle.net/10400.21/21907
dc.language.isoeng
dc.peerreviewedyes
dc.publisherSpringer Science and Business Media LLC
dc.relation.hasversionhttps://aidsrestherapy.biomedcentral.com/articles/10.1186/s12981-025-00751-7
dc.relation.ispartofAIDS Research and Therapy
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectAIDS-related gene variants
dc.subjectAllelic frequency
dc.subjectHIV infection
dc.subjectAngola
dc.subjectLuanda
dc.titleDistribution of CCR5-Delta32, CCR2-64I, and SDF1-3’A host genetic factors in HIV-infected and uninfected individuals in Luanda, Angolaeng
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue1
oaire.citation.startPage54
oaire.citation.titleAIDS Research and Therapy
oaire.citation.volume22
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameBrito
person.givenNameMiguel
person.identifier.ciencia-id231F-F341-7E93
person.identifier.orcid0000-0001-6394-658X
person.identifier.ridA-7970-2016
person.identifier.scopus-author-id35224551000
relation.isAuthorOfPublication4252d8e0-800c-4d67-8b13-0b711d860669
relation.isAuthorOfPublication.latestForDiscovery4252d8e0-800c-4d67-8b13-0b711d860669

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