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- Determinantes da escolha do justo valor como base de mensuração de ativos não financeiros na União EuropeiaPublication . Rodrigues Ferreira Costa Cid, Marçal José; Pires, RuiO presente trabalho visa identificar as determinantes da escolha do justo valor na mensuração subsequente de propriedades de investimento, de ativos fixos tangíveis e de ativos intangíveis por parte das entidades que, na União Europeia, relatam de acordo com as IFRS. Tendo por base as linhas de investigação de diversos estudos, este trabalho assenta numa análise quantitativa, usando um modelo econométrico logit, com base nos relatórios e contas de 118 empresas (PSI 20, STOXX 50 e EURONEXT 100), representativa de entidades da União Europeia. Os resultados obtidos indicam que o peso das propriedades de investimento no ativo total, a dimensão da empresa, os resultados por ação, a variação do resultado integral, a existência de remuneração variável nos administradores e as participações qualificadas aumentam a probabilidade de adoção do justo valor. A relação observada na remuneração variável e nas participações qualificadas proporcionam alguma evidência que corrobora a teoria da agência. Por outro lado, o alisamento dos resultados, a variação do lucro, o peso dos ativos intangíveis, ativos fixos tangíveis e propriedades de investimento no ativo total e o peso do EBITDA no volume de negócios diminuem a probabilidade de adoção do justo valor. Os resultados obtidos revelam ainda que as empresas portuguesas adotam mais frequentemente o justo valor como base de mensuração subsequente, comparativamente com outras empresas da União Europeia. Ao analisar os determinantes da adoção do justo valor, o presente estudo mostra-se relevante para um vasto leque de agentes, nomeadamente auditores, analistas, reguladores, organismos de normalização contabilística, entre outros.
- Next-generation wound care: a scoping review on probiotic, prebiotic, synbiotic, and postbiotic cutaneous formulationsPublication . Machado, Patrícia; Ribeiro, Felipe Neme; Giublin, Fernanda Wroblevski; Mieres, Naomi Gerzvolf; Tonin, Fernanda; Pontarolo, Roberto; Sari, Marcel Marcondes; Lazo, Raul Luna; Ferreira, Luana MotaBackground/Objectives: Chronic wounds represent a significant socioeconomic burden, affecting 1–2% of the global population. Wound healing is a complex process involving inflammation, cell proliferation, and tissue remodeling, but factors such as infections, diabetes, aging, and poor nutrition can impair recovery, leading to chronic wounds. Given these challenges, researchers have explored topical probiotics, synbiotics, and postbiotics as alternative strategies. Strains like Lactobacillus and Bifidobacterium contribute to skin restoration by producing antimicrobial, anti-inflammatory, and immunomodulatory compounds, offering a novel approach to cutaneous restoration. Our study aims to address the potential effects of topical probiotic, synbiotic, and postbiotic formulations for wound healing applications by means of a broad scoping review and evidence-gap mapping. Methods: A systematic literature search of preclinical studies (in vitro and in vivo) was performed in PubMed, Scopus, and Web of Science (January 2025), yielding 3052 articles after duplicates removal, of which 44 met the inclusion criteria. Results: These studies were published between 1986 and 2024, mostly by China (27.3%) and Iran (25.0%). Probiotics were frequently evaluated among the studies included (47.7%) (with Lactobacillus plantarum being the most assessed strain), followed by postbiotics (36.4%) (with predominant use of cell-free supernatants) and synbiotics (15.9%) (especially fructooligosaccharides). Dosage forms included gels (44.4%), films (15.6%), and ointments (13.3%). Conclusions: Most studies indicate that probiotics, synbiotics, and postbiotics have antimicrobial and anti-inflammatory properties, while promoting angiogenesis, tissue regeneration, and skin barrier restoration. The use of different delivery systems may additionally enhance therapeutic outcomes by accelerating wound closure, reducing bacterial load, and modulating immune response. However, methodological limitations in animal studies highlight the need for greater experimental rigor. Further robust clinical trials are essential to confirm efficacy and safety before clinical application of these formulations.
- Safety profile of gestrinone: a systematic reviewPublication . Fagundes, Vitor Luís; Marques, Nathália Barreiro; Lima, Amanda Franco de; Cobre, Alexandre de Fátima; Tonin, Fernanda; Lazo, Raul Luna; Pontarolo, RobertoBackground: Gestrinone is a synthetic hormone derived from 19-nortestosterone, exhibiting androgenic, anabolic, anti-progestogenic, and antiestrogenic effects. Gestrinone subcutaneous implants have been used “off label” for aesthetic purposes due to their anabolic action, promoting accelerated metabolism and muscle gain. Objective: Our goal is to conduct a systematic review focused exclusively on identifying the safety profile of gestrinone use, without addressing efficacy. Methods: This systematic review was performed according to the Joanna Briggs Institute and Cochrane Collaboration recommendations and is reported following the Preferred Reporting Items for Systematic Reviews and Network Meta-Analyses. This article’s searches were carried out in the PubMed, Embase, and Web of Science databases. Results: A total of 32 articles were included in this study. The reported adverse events associated with the use of gestrinone were amenorrhea (41.4% of cases), acne, seborrhea (42.7% of reports), decreased libido (26.5%), and hot flushes (24.2%). Other nonspecific symptoms, such as hoarseness and cramps, were also fairly reported (3.5% and 18.6%, respectively). Other reported effects were associated with breast size reduction (23.7% of patients) and increased transaminases (15.1%). Most studies (40%, n = 24 studies) found significant weight gain (ranging from 0.9 to 8 kg per patient). Abnormalities in bone mineral density were reported in four studies. Conclusions: The evidence remains insufficient to fully understand the risks of gestrinone use associated with its widespread, unregulated use. Thus, further standardized studies and regulatory oversight to ensure patient safety are needed to mitigate potential health risks.
- Distribution of CCR5-Delta32, CCR2-64I, and SDF1-3’A host genetic factors in HIV-infected and uninfected individuals in Luanda, AngolaPublication . Sebastião, Cruz S.; Pimentel, Victor; Jandondo, Domingos; Sebastião, Joana M. K.; Sacomboio, Euclides; Pingarilho, Marta; Brito, Miguel; Cassinela, Edson kuatelela; Vasconcelos, Jocelyne Neto de; Abecasis, Ana B.; Morais, JoanaBackground: The HIV/AIDS pandemic remains a public health concern. Studies on host genetic polymorphisms that confer resistance to HIV-1 infection or delay HIV disease progression are scarce in African countries. Herein, we investigate the proportion of the mutated phenotype of the AIDS-related polymorphisms CCR5-Delta32, CCR2-64I, and SDF1-3'A in HIV-infected and uninfected individuals in Luanda, the capital of Angola, a sub-Saharan African country. Methods: This was a cross-sectional study conducted with 284 individuals, of whom 159 were HIV-negative and 125 were HIV-positive. The CCR5-Delta32, CCR2-64I, and SDF1-3'A genotypes were detected by conventional PCR and visualised on a 2% agarose gel. A Chi-square test determined the frequency of each genetic variant and was deemed significant when p < 0.05. Results: The frequency of CCR5-Delta32, CCR2-64I, and SDF1-3 A was 0% (0/272), 60.2% (154/256), and 42.5% (114/268), respectively. CCR2-64I and SDF1-3 A polymorphisms were statistically related to HIV infection (p < 0.001). Statistically significant was observed between ABO blood groups (p = 0.006) and HIV-1 subtype (p = 0.015) with CCR2-64I. Also, the age group (p = 0.024) and RH blood group (p = 0.018) were statistically related to the distribution of SDF1-3 A polymorphism. Conclusions: We found no CCR5-Delta32 allele, while CCR2-64I and SDF1-3'A were found and presented a relationship with HIV infection, age, ABO/RH blood group, and HIV-1 subtypes. The observed associations of CCR2-64I and SDF1-3'A with HIV underscore the urgent need for further multidisciplinary research, with potential implications for targeted prevention and public health strategies. Therefore, studies investigating biological and non-biological factors related to susceptibility to HIV infection and AIDS progression or death should be conducted in Angola.
- Prevalence and factors associated with inadequate intake of fruits and vegetables in a population from Northern AngolaPublication . Morais, Humberto; Cupessala, Vizé Preciosa; Pedro, João Mário; Brito, Miguel; Gonçalves, Mauer A. A.Background: The World Health Organization recommends a minimum intake of 400 g or five servings of Fruits and Vegetables (FVs) per day for the prevention of chronic diseases. Objective: The present study aims to describe the prevalence and factors associated with inadequate FV intake in a sample of Angolan adults who participated in the CardioBengo study. Methods: It is a subset analysis of CardioBengo, a community-based cross-sectional observational study conducted in the Dande Municipality, Bengo Province, Angola. Results: The sample included 2161 individuals aged 18 to 84, with 64.1% being women. 57.2% of participants were below high school, and only 3.1% attended higher education. 61.7% were married, and 48.3% had a monthly income below 150 USD. The prevalence of insufficient FV consumption in the sample was 86.2%. It was observed that female gender, low education level, and the age group of 20-29 years were associated with inadequate FV intake (p = 0.010, p = 0.001, and p = 0.006, respectively). Conclusion: There was no association between FV consumption and cardiovascular risk factors. A prevalence of FV consumption well below current recommendations was identified. The identified risk factors can serve as a strategy to increase FV consumption in this population.
- Balloon pulmonary angioplasty and riociguat in the management of chronic thromboembolic pulmonary hypertension: a systematic reviewPublication . Araújo, Patrícia; Calé, Rita; Pereira, Ernesto; Ferreira, Filipa; Alegria, Sofia; Pereira, Hélder; Coelho, AndréBackground: No systematic review has been published comparing the effectiveness and safety of balloon pulmonary angioplasty (BPA) and riociguat in patients with chronic thromboembolic pulmonary hypertension (CTEPH) across studies that evaluate both treatment methods. Methods: A literature search was conducted using PubMed, ScienceDirect, and Elsevier. Clinical, functional, and hemodynamic effectiveness criteria were analysed, as well as complications related to both interventions. Results: Five studies were reviewed, including randomized clinical trials and observational studies, comprising 184 patients who underwent riociguat and BPA, 94 patients who underwent BPA alone, and 79 who underwent riociguat alone. Patients receiving combination therapy demonstrated a more significant improvement in WHO-FC, PVR, and CO (≈1.13 L/min) than monotherapy (BPA: ≈0.45 L/min and riociguat: ≈0.84 L/min). Regarding the 6MWD, patients who started with Riociguat before combination therapy showed a greater improvement (≈78 m) than those on monotherapy (BPA: ≈46.9 m and riociguat: ≈38.2 m). The reduction in mPAP was greater in patients treated with BPA alone (≈-17.6 mmHg) compared to riociguat alone (≈-5.4 mmHg) or combination therapy (≈-12.2 mmHg). In the BPA group, the rate of life-threatening complications was very low, with haemoptysis or pulmonary haemorrhage being the most common adverse events (15%-44%). In the riociguat group, dizziness, headaches, gastrointestinal reflux, vomiting, and nausea were reported (15%-23%). Among patients undergoing both treatments, the vascular injury rate was <11 %, with the most common adverse event being the need for non-invasive ventilation (30 %). Conclusions: Combination therapy appears to be more effective than monotherapy, without being associated with major adverse events in patients diagnosed with CTEPH.
- O porquê da importância do desenvolvimento de competências de literacia da informação no ensino superior? Exemplos com a IAPublication . Lopes, Carlos; Antunes, Maria Luz; Sanches, TatianaO ensino superior representa um ambiente complexo, exigente e desafiador. Os estudantes desejam ampliar o seu conhecimento e compreensão da informação, necessitando navegar e usar as fontes de informação de forma ética e legal. Em 2023, a tecnologia de IA generativa registou taxas de adoção sem precedentes, tornando a a tecnologia adotada mais rapidamente na história. Assistimos a uma exploração contínua das ferramentas de IA geradoras de impacto potencial e, reconhecendo o seu potencial, dividimo nos entre entusiasmo e escrutínio cauteloso. Devemos avaliar o impacto e as experiências que já existem na implementação destas tecnologias. Questões como enganos, falácias e desinformação podem prejudicar o ensino e formação. Portanto, é vital que a utilização da IA seja feita com cautela e se desenvolvam proteções contra o uso indevido. Existe uma possível resposta ou ajuda proveniente da literacia da informação?
- Revistas, editoras e congressos predadores e a investigação científicaPublication . Antunes, Maria Luz; Lopes, Carlos; Sanches, TatianaA pressão para publicar e a dificuldade em discernir a revista legítima da ilegítima e a editora confiável da não confiável fomentam um ambiente favorável à proliferação de publicações questionáveis. Também os congressos predadores têm proliferado nos últimos anos, movimentando elevados montantes e onde todos pagam para circular. Os investigadores devem, numa postura exigente e informada, no interesse da confiabilidade da (e na) ciência, ter boas práticas de investigação, evitando a inclusão de dados falsos, plagiados ou manipulados, que prejudicam a qualidade dos resultados e das conclusões, influenciando a evidência científica, a ciência e a sociedade. Objetivos do workshop: 1. Analisar e caracterizar o fenómeno a partir da literatura indexada na JSTOR, ProQuest, PubMed, Scopus e Web of Science, desde 2012 à atualidade. 2. Analisar o impacto das revistas, editoras e congressos predadores na investigação científica, identificando características e o conhecimento adquirido. 3. Dotar doutorandos, professores e investigadores com um conjunto de recomendações orientadoras e de alerta face ao fenómeno.
- Assessing the impact of nanoplastics in biological systems: systematic review of in vitro animal studiesPublication . Viana, Maria; Tonin, Fernanda; Ladeira, CarinaNanoplastic (NP) pollution has emerged as a growing concern due to its potential impact on human health, although its adverse effects on different organ systems are not yet fully understood. This systematic scoping review, conducted following international guidelines, aimed to map the current evidence on the biological effects of NPs. In vitro animal studies assessing cellular damage caused by exposure to any type of NP were searched on PubMed, Web of Science, and Scopus. Data on primary outcomes related to genotoxicity and cytotoxicity (cell viability, oxidative stress, inflammation, DNA and cytoplasmic damage, apoptosis) were extracted from the included studies, and overall reporting quality was assessed. A total of 108 articles published between 2018 and 2024, mostly by China (54%), Spain (14%), and Italy (9%), were included. Polystyrene (PS) was the most frequently studied polymer (85%). NP sizes in solution ranged from 15 to 531 nm, with a higher prevalence in the 40–100 nm range (38%). The overall quality of studies was rated as moderate (60%), with many lacking essential details about cell culture conditions (e.g., pH of the medium, passage number, substances used). A higher frequency of negative effects from NP exposure was observed in respiratory cell lines, while immune, digestive, and hepatic cell lines showed greater resistance. Nervous, urinary, and connective tissue systems were impacted by NPs. Positively charged and smaller PS particles were consistently associated with higher toxicity across all systems. In summary, this review highlights the multifactorial nature of NP toxicity, influenced by size, surface charge, and polymer type. It also reveals a significant knowledge gap, stemming from the predominant use of immortalized monocultures exposed to commercially available PS NPs, the limited use of environmentally relevant particles, and the underutilization of advanced experimental models (e.g., organ-on-chip systems) that better mimic physiological conditions.
- Strategies for increased adherence to the Mediterranean or healthy diet in university food services: a systematic reviewPublication . Silva, Sofia Sousa; Rocha, Ada; Viegas, CláudiaThe Mediterranean diet (MD) has been recognised as a healthy and sustainable diet model. Despite this, current eating habits diverge significantly from established dietary recommendations, namely the MD among young university students. The eating habits of young people are characterised by a high consumption of energy-dense foods and a low consumption of vegetables and fruit. Thus, university canteen food services are essential in promoting a healthy and sustainable diet. This systematic review aimed to identify the strategies for promoting adherence to the MD and healthy diets in Higher Education food service. This systematic review was based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). Of the 39 studies that were retrieved, all focused on strategies to improve healthy eating, and none specifically used the term "Mediterranean". Studies were conducted in different countries worldwide. Architectural nudges, discounts on healthy food and nutritional information were identified as successful strategies, especially among females and students with higher nutrition education. A combination of nudging strategies in food service is a promising way to promote healthier food habits.
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