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Advisor(s)
Abstract(s)
According to the WHO, air quality affects around 40 million people, contributing to around 21,000 premature deaths per year. Severe respiratory diseases, such as asthma and chronic obstructive pulmonary disorder, can be promoted by air pollution, which has already been documented; this is one of the reasons why air quality is a very relevant factor for human health and well-being. Aerosols are an aggregation of solid or liquid particles dispersed in the air and can be found in the form of dust or fumes. Aerosols can be easily inhaled or absorbed by the skin, leading to adverse health effects according to their sizes ranging from the nanometre to the millimeter scale. Based on the PRISMA methodology and using the Rayyan QCRI platform, it was possible to assess more than four hundred research articles. This systematic review study aimed to understand the impact of particles on pulmonary endothelial cells, namely particulate matter in different sizes, cigarette smoke, diesel exhaust particles, and carbon black. The main conclusions were that particles induce multiple health effects on endothelial cells, namely endothelial dysfunction, which can lead to apoptosis and necrosis, and it may also cause necroptosis in lung structure.
Description
Project IDI&CA PLASCONGEN (IPL/2021/PLASCONGEN_ESTeSL).
Keywords
Pulmonary endothelial cells Particles Impact Exposure Pollution Projeto IDI&CA PLASCONGEN IPL/2021/PLASCONGEN_ESTeSL
Citation
Almeida-Silva M, Cardoso J, Alemão C, Santos S, Monteiro A, Manteigas V, Marques-Ramos A. Impact of particles on pulmonary endothelial cells. Toxics. 2022;10(6):312.
Publisher
MDPI