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Impact of particles on pulmonary endothelial cells

2022-06Journal article Open access
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dc.contributor.authorAlmeida-Silva, Marina
dc.contributor.authorCardoso, Jéssica
dc.contributor.authorAlemão, Catarina
dc.contributor.authorSantos, Sara
dc.contributor.authorMonteiro, Ana
dc.contributor.authorManteigas, Vítor
dc.contributor.authorMarques-Ramos, Ana
dc.date.accessioned2022-06-20T13:51:13Z
dc.date.available2022-06-20T13:51:13Z
dc.date.issued2022-06
dc.descriptionProject IDI&CA PLASCONGEN (IPL/2021/PLASCONGEN_ESTeSL).pt_PT
dc.description.abstractAccording to the WHO, air quality affects around 40 million people, contributing to around 21,000 premature deaths per year. Severe respiratory diseases, such as asthma and chronic obstructive pulmonary disorder, can be promoted by air pollution, which has already been documented; this is one of the reasons why air quality is a very relevant factor for human health and well-being. Aerosols are an aggregation of solid or liquid particles dispersed in the air and can be found in the form of dust or fumes. Aerosols can be easily inhaled or absorbed by the skin, leading to adverse health effects according to their sizes ranging from the nanometre to the millimeter scale. Based on the PRISMA methodology and using the Rayyan QCRI platform, it was possible to assess more than four hundred research articles. This systematic review study aimed to understand the impact of particles on pulmonary endothelial cells, namely particulate matter in different sizes, cigarette smoke, diesel exhaust particles, and carbon black. The main conclusions were that particles induce multiple health effects on endothelial cells, namely endothelial dysfunction, which can lead to apoptosis and necrosis, and it may also cause necroptosis in lung structure.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationAlmeida-Silva M, Cardoso J, Alemão C, Santos S, Monteiro A, Manteigas V, Marques-Ramos A. Impact of particles on pulmonary endothelial cells. Toxics. 2022;10(6):312.pt_PT
dc.identifier.doi10.3390/toxics10060312pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/14713
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationProject IDI&CA PLASCONGEN (IPL/2021/PLASCONGEN_ESTeSL)pt_PT
dc.relation.publisherversionhttps://www.mdpi.com/2305-6304/10/6/312pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectPulmonary endothelial cellspt_PT
dc.subjectParticlespt_PT
dc.subjectImpactpt_PT
dc.subjectExposurept_PT
dc.subjectPollutionpt_PT
dc.subjectProjeto IDI&CA PLASCONGENpt_PT
dc.subjectIPL/2021/PLASCONGEN_ESTeSLpt_PT
dc.titleImpact of particles on pulmonary endothelial cellspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue6pt_PT
oaire.citation.startPage312pt_PT
oaire.citation.titleToxicspt_PT
oaire.citation.volume10pt_PT
person.familyNameManteigas
person.familyNameMarques-Ramos
person.givenNameVítor
person.givenNameAna
person.identifier.ciencia-id291D-1CDE-FDDB
person.identifier.ciencia-id0617-3550-881E
person.identifier.orcid0000-0001-8870-1765
person.identifier.orcid0000-0003-2655-8806
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication0bcda13c-ba69-429f-9337-956ab30cdff6
relation.isAuthorOfPublication0b8d516d-bf23-4db0-8224-d33e28d309ac
relation.isAuthorOfPublication.latestForDiscovery0bcda13c-ba69-429f-9337-956ab30cdff6

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