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Advisor(s)
Abstract(s)
The main purpose of the present study is to determine if the circadian rhythms present in the human bone marrow are likely to influence 3’- deoxy- 3’-[18F] Fluorothymidine (18F-FLT) uptake in the same organ. The 18F-FLT is a Thymidine analogous proliferation agent. The relatively high physiological uptake of this tracer in the bone marrow diminishes the Tumor/Background (T/B) ratio, decreasing the detection accuracy of PET/CT and possibly affecting SUV quantifications.
Description
Keywords
Nuclear medicine Endogenous circadian rhythms Human bone marrow 18F-Fluorothymidine
Citation
Varela NM, Lucena F, Carapinha MJ, Vieira L. Analysis of the interference of endogenous circadian rhythms on 3'- deoxy- 3'- [18F]Fluorothymidine physiological uptake at the human bone marrow. Eur j Nucl Med Mol Imaging. 2011;38(2 Suppl):S452.