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microRNAs are key regulators of the development and functional differentiation of γδ T cell subsets

2023-06Conference object Open access
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dc.contributor.authorInácio, Daniel
dc.contributor.authorAmado, Tiago
dc.contributor.authorSilva, Marta
dc.contributor.authorSobral, Daniel
dc.contributor.authorCunha, Carolina
dc.contributor.authorEnguita, Francisco
dc.contributor.authorPamplona, Ana
dc.contributor.authorGomes, Anita Q.
dc.contributor.authorSilva-Santos, Bruno
dc.date.accessioned2024-01-16T09:42:34Z
dc.date.available2024-01-16T09:42:34Z
dc.date.issued2023-06
dc.description.abstractThe ability of murine γδ T cells to rapidly produce the pro-inflammatory cytokines interleukin-17 (IL-17) or interferon-γ (IFN-γ) underlies their crucial and non-redundant roles in several (patho)physiological contexts, such as tissue homeostasis, infection, autoimmunity and cancer. This capacity stems from a complex process of ‘developmental pre-programming’ in the thymus, after which a large fraction of γδ T cells migrate to peripheral sites already committed to producing IL-17 or IFN-γ, unlike their ab T cell counterparts1. So far, several miRNAs have been implied in the control of the differentiation and IFN-γ and IL-17 levels by ab Th1 and Th17 cells, respectively2. However, little is known about the action of these post-transcriptional regulators on γδ T cell differentiation. Schmolka et al. showed that miR-146a is selectively enriched in IL-17-biased CD27- γδ T cells and restricts their co-production of IFN-γ by targeting Nod1 mRNA, therefore regulating γδ T cell plasticity3. This isolated work illustrates the need of a more comprehensive study of the miRNA repertoires of γδ T cells and of the regulatory networks they take part in the control of IFN-γ and IL-17 production by these cells.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationInácio D, Amado T, Sobral D, Cunha C, Silva M, Gomes AQ, et al. microRNAs are key regulators of the development and functional differentiation of γδ T cell subsets. In: 10th International γδ T Cell Conference, Fundação Champalimaud (Lisbon), June 20-23, 2023.pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/16890
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relation.publisherversionhttps://www.spimunologia.org/wp-content/uploads/2023/06/GammaDelta2023-AF-PROGRAM-IN-DETAIL.pdfpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectMicroRNApt_PT
dc.subjectγδ T cell subsetspt_PT
dc.subjectPro-inflammatory cytokinespt_PT
dc.titlemicroRNAs are key regulators of the development and functional differentiation of γδ T cell subsetspt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.citation.conferencePlaceLisboapt_PT
person.familyNameGomes
person.givenNameAnita
person.identifier.ciencia-id4B10-E015-52B7
person.identifier.orcid0000-0002-3348-0448
person.identifier.ridC-3580-2014
person.identifier.scopus-author-id7202386033
rcaap.rightsopenAccesspt_PT
rcaap.typeconferenceObjectpt_PT
relation.isAuthorOfPublication2b5a3f0a-29c2-4ecd-a83f-50d0b99a4875
relation.isAuthorOfPublication.latestForDiscovery2b5a3f0a-29c2-4ecd-a83f-50d0b99a4875

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