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Advisor(s)
Abstract(s)
The ability of murine γδ T cells to rapidly produce the pro-inflammatory cytokines interleukin-17 (IL-17) or interferon-γ (IFN-γ) underlies their crucial and non-redundant roles in several (patho)physiological contexts, such as tissue homeostasis, infection, autoimmunity and cancer. This capacity stems from a complex process of ‘developmental pre-programming’ in the thymus, after which a large fraction of γδ T cells migrate to peripheral sites already committed to producing IL-17 or IFN-γ, unlike their ab T cell counterparts1. So far, several miRNAs have been implied in the control of the differentiation and IFN-γ and IL-17 levels by ab Th1 and Th17 cells, respectively2. However, little is known about the action of these post-transcriptional regulators on γδ T cell differentiation. Schmolka et al. showed that miR-146a is selectively enriched in IL-17-biased CD27- γδ T cells and restricts their co-production of IFN-γ by targeting Nod1 mRNA, therefore regulating γδ T cell plasticity3. This isolated work illustrates the need of a more comprehensive study of the miRNA repertoires of γδ T cells and of the regulatory networks they take part in the control of IFN-γ and IL-17 production by these cells.
Description
Keywords
MicroRNA γδ T cell subsets Pro-inflammatory cytokines
Pedagogical Context
Citation
Inácio D, Amado T, Sobral D, Cunha C, Silva M, Gomes AQ, et al. microRNAs are key regulators of the development and functional differentiation of γδ T cell subsets. In: 10th International γδ T Cell Conference, Fundação Champalimaud (Lisbon), June 20-23, 2023.