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Advisor(s)
Abstract(s)
Purpose: Sickle cell disease (SCD) is a genetic blood disorder that affects the shape and transport of red blood cells (RBCs) in blood vessels, leading to various clinical complications. The pharmacological reactivation of Fetal Hemoglobin (HbF) is considered to be a viable therapeutic method in SCD. In this regard, hydroxyurea (HU), a powerful ribonucleotide reductase inhibitor, is being employed as a HbF-inducing pharmaceutical. However, its cytotoxicity, carcinogenic potential, and variable effects limit its use. Thus, a major challenge today is to identify new agents, with high HbF-inducing activity, low cytotoxicity, and available in low- and middle-income countries, such as natural compounds. Quercetin, a natural flavonoid, has been identified as a potential HbF inducer. The main aim of this work was to evaluate Quercetin's role in the reactivation of fetal hemoglobin (HbF) by analyzing the expression of globin and HbF regulatory/silencing genes.
Description
IDI&CA-IPL/2021/EpiCa/ESTeSL
FCT_UIDB/05608/2020. FCT_UIDP/05608/2020.
FCT_UIDB/05608/2020. FCT_UIDP/05608/2020.
Keywords
Sickle cell disease Fetal hemoglobin Quercetin IDI&CA-IPL/2021/EpiCa/ESTeSL FCT_UIDB/05608/2020 FCT_UIDP/05608/2020
Citation
Canteiro B, Delgadinho M, Ginete C, Brito M, Gomes AQ, Ribeiro E, et al. Effects of quercetin in transcriptional regulation of fetal hemoglobin. In: 4th Global Congress on Sickle Cell Disease [hybrid congress], Paris (France), June 16-18, 2022. Poster 069. HemaSphere. 2022;6(Aug):49-50.