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Effects of quercetin in transcriptional regulation of fetal hemoglobin

2022-06Conference object Open access
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dc.contributor.authorCanteiro, B.
dc.contributor.authorMendes, M.
dc.contributor.authorDelgadinho, Mariana
dc.contributor.authorOliveira, K.
dc.contributor.authorGinete, Catarina
dc.contributor.authorGomes, M.
dc.contributor.authorBrito, Miguel
dc.contributor.authorGomes, Anita Q.
dc.contributor.authorRibeiro, Edna
dc.date.accessioned2022-08-23T14:25:25Z
dc.date.available2022-08-23T14:25:25Z
dc.date.issued2022-06
dc.descriptionIDI&CA-IPL/2021/EpiCa/ESTeSLpt_PT
dc.descriptionFCT_UIDB/05608/2020. FCT_UIDP/05608/2020.pt_PT
dc.description.abstractPurpose: Sickle cell disease (SCD) is a genetic blood disorder that affects the shape and transport of red blood cells (RBCs) in blood vessels, leading to various clinical complications. The pharmacological reactivation of Fetal Hemoglobin (HbF) is considered to be a viable therapeutic method in SCD. In this regard, hydroxyurea (HU), a powerful ribonucleotide reductase inhibitor, is being employed as a HbF-inducing pharmaceutical. However, its cytotoxicity, carcinogenic potential, and variable effects limit its use. Thus, a major challenge today is to identify new agents, with high HbF-inducing activity, low cytotoxicity, and available in low- and middle-income countries, such as natural compounds. Quercetin, a natural flavonoid, has been identified as a potential HbF inducer. The main aim of this work was to evaluate Quercetin's role in the reactivation of fetal hemoglobin (HbF) by analyzing the expression of globin and HbF regulatory/silencing genes.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationCanteiro B, Delgadinho M, Ginete C, Brito M, Gomes AQ, Ribeiro E, et al. Effects of quercetin in transcriptional regulation of fetal hemoglobin. In: 4th Global Congress on Sickle Cell Disease [hybrid congress], Paris (France), June 16-18, 2022. Poster 069. HemaSphere. 2022;6(Aug):49-50.pt_PT
dc.identifier.doi10.1097/01.HS9.0000873164.96343.19pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/14933
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relation.publisherversionhttps://journals.lww.com/hemasphere/Fulltext/2022/08004/P_069__EFFECTS_OF_QUERCETIN_IN_TRANSCRIPTIONAL.90.aspxpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectSickle cell diseasept_PT
dc.subjectFetal hemoglobinpt_PT
dc.subjectQuercetinpt_PT
dc.subjectIDI&CA-IPL/2021/EpiCa/ESTeSLpt_PT
dc.subjectFCT_UIDB/05608/2020pt_PT
dc.subjectFCT_UIDP/05608/2020pt_PT
dc.titleEffects of quercetin in transcriptional regulation of fetal hemoglobinpt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.citation.endPage50pt_PT
oaire.citation.startPage49pt_PT
oaire.citation.titleHemaSpherept_PT
oaire.citation.volume6pt_PT
person.familyNameNeves Delgadinho
person.familyNameHonrado Ginete
person.familyNameBrito
person.familyNameGomes
person.familyNameRibeiro
person.givenNameMariana Isabel
person.givenNameAna Catarina
person.givenNameMiguel
person.givenNameAnita
person.givenNameEdna
person.identifierCAJ-5082-2022
person.identifier.ciencia-id231E-02E3-D9A9
person.identifier.ciencia-id8715-F62E-1E0F
person.identifier.ciencia-id231F-F341-7E93
person.identifier.ciencia-id4B10-E015-52B7
person.identifier.ciencia-idC414-CDF2-D35A
person.identifier.orcid0000-0003-0586-9154
person.identifier.orcid0000-0002-2334-782X
person.identifier.orcid0000-0001-6394-658X
person.identifier.orcid0000-0002-3348-0448
person.identifier.orcid0000-0003-1316-7750
person.identifier.ridA-7970-2016
person.identifier.ridC-3580-2014
person.identifier.scopus-author-id35224551000
person.identifier.scopus-author-id7202386033
rcaap.rightsopenAccesspt_PT
rcaap.typeconferenceObjectpt_PT
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