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Advisor(s)
Abstract(s)
Purpose: Sickle cell disease (SCD) is one of the most common human genetic disorders, which is caused by a single point mutation (Glu6Val) on the HBB gene. Currently, one of the treatments for this global health problem involves the induction of fetal hemoglobin (HbF). There are some drugs on the market that pharmacologically induce HbF, namely Hydroxyurea (HU), however, their safety concerns and the expensive cost in low- and middle-income countries limit their use. In this context, it is essential to study novel fetal hemoglobin-inducing compounds that have fewer adverse effects and are widely available, such as natural compounds. Therefore, the main aim of this work was to evaluate the effects of Carica Papaya methanolic leaf extracts (CPMLE) in HbF reactivation.
Description
IDI&CA-IPL/2021/EpiCa/ESTeSL
FCT_UIDB/05608/2020. FCT_UIDP/05608/2020.
FCT_UIDB/05608/2020. FCT_UIDP/05608/2020.
Keywords
Sickle cell disease Fetal hemoglobin Hydroxyurea IDI&CA-IPL/2021/EpiCa/ESTeSL FCT_UIDB/05608/2020 FCT_UIDP/05608/2020
Citation
Mendes M, Delgadinho M, Oliveira K, Ginete C, Ribeiro E, Brito M, Gomes AQ, et al. Effects of Carica papaya leaf extracts in transcriptional regulation of fetal hemoglobin. In: 4th Global Congress on Sickle Cell Disease [hybrid congress], Paris (France), June 16-18, 2022. Poster 091. HemaSphere. 2022;6(Aug):58-9.