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Effects of Carica papaya leaf extracts in transcriptional regulation of fetal hemoglobin

2022-06Conference object Open access
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dc.contributor.authorMendes, M.
dc.contributor.authorCanteiro, Beatriz
dc.contributor.authorDelgadinho, Mariana
dc.contributor.authorOliveira, Ketlyn
dc.contributor.authorGinete, Catarina
dc.contributor.authorGomes, Mário
dc.contributor.authorRibeiro, Edna
dc.contributor.authorBrito, Miguel
dc.contributor.authorGomes, Anita Q.
dc.date.accessioned2022-08-23T13:58:32Z
dc.date.available2022-08-23T13:58:32Z
dc.date.issued2022-06
dc.descriptionIDI&CA-IPL/2021/EpiCa/ESTeSLpt_PT
dc.descriptionFCT_UIDB/05608/2020. FCT_UIDP/05608/2020.pt_PT
dc.description.abstractPurpose: Sickle cell disease (SCD) is one of the most common human genetic disorders, which is caused by a single point mutation (Glu6Val) on the HBB gene. Currently, one of the treatments for this global health problem involves the induction of fetal hemoglobin (HbF). There are some drugs on the market that pharmacologically induce HbF, namely Hydroxyurea (HU), however, their safety concerns and the expensive cost in low- and middle-income countries limit their use. In this context, it is essential to study novel fetal hemoglobin-inducing compounds that have fewer adverse effects and are widely available, such as natural compounds. Therefore, the main aim of this work was to evaluate the effects of Carica Papaya methanolic leaf extracts (CPMLE) in HbF reactivation.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMendes M, Delgadinho M, Oliveira K, Ginete C, Ribeiro E, Brito M, Gomes AQ, et al. Effects of Carica papaya leaf extracts in transcriptional regulation of fetal hemoglobin. In: 4th Global Congress on Sickle Cell Disease [hybrid congress], Paris (France), June 16-18, 2022. Poster 091. HemaSphere. 2022;6(Aug):58-9.pt_PT
dc.identifier.doi10.1097/01.HS9.0000873252.25768.51pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/14931
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relationIDI&CA-IPL/2021/EpiCa/ESTeSLpt_PT
dc.relation.publisherversionhttps://journals.lww.com/hemasphere/Fulltext/2022/08004/P_091__EFFECTS_OF_CARICA_PAPAYA_LEAF_EXTRACTS_IN.112.aspxpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectSickle cell diseasept_PT
dc.subjectFetal hemoglobinpt_PT
dc.subjectHydroxyureapt_PT
dc.subjectIDI&CA-IPL/2021/EpiCa/ESTeSLpt_PT
dc.subjectFCT_UIDB/05608/2020pt_PT
dc.subjectFCT_UIDP/05608/2020pt_PT
dc.titleEffects of Carica papaya leaf extracts in transcriptional regulation of fetal hemoglobinpt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.citation.endPage59pt_PT
oaire.citation.startPage58pt_PT
oaire.citation.titleHemaSpherept_PT
oaire.citation.volume6pt_PT
person.familyNameNeves Delgadinho
person.familyNameHonrado Ginete
person.familyNameRibeiro
person.familyNameBrito
person.familyNameGomes
person.givenNameMariana Isabel
person.givenNameAna Catarina
person.givenNameEdna
person.givenNameMiguel
person.givenNameAnita
person.identifierCAJ-5082-2022
person.identifier.ciencia-id231E-02E3-D9A9
person.identifier.ciencia-id8715-F62E-1E0F
person.identifier.ciencia-idC414-CDF2-D35A
person.identifier.ciencia-id231F-F341-7E93
person.identifier.ciencia-id4B10-E015-52B7
person.identifier.orcid0000-0003-0586-9154
person.identifier.orcid0000-0002-2334-782X
person.identifier.orcid0000-0003-1316-7750
person.identifier.orcid0000-0001-6394-658X
person.identifier.orcid0000-0002-3348-0448
person.identifier.ridA-7970-2016
person.identifier.ridC-3580-2014
person.identifier.scopus-author-id35224551000
person.identifier.scopus-author-id7202386033
rcaap.rightsopenAccesspt_PT
rcaap.typeconferenceObjectpt_PT
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relation.isAuthorOfPublicationdfb2fbba-17ff-42fb-905a-fcfc8f326e1c
relation.isAuthorOfPublicationa571bf34-bcda-49ca-b5cb-4cdecbb3d9c7
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