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Functional food components, intestinal permeability and inflammatory markers in patients with inflammatory bowel disease

2021-02Journal article Open access
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dc.contributor.authorLacerda, Joana Franco
dc.contributor.authorLagos, Ana Catarina
dc.contributor.authorCarolino, Elisabete
dc.contributor.authorSilva-Herdade, Ana Santos
dc.contributor.authorSilva, Manuel
dc.contributor.authorGuerreiro, Catarina Sousa
dc.date.accessioned2021-02-25T11:20:30Z
dc.date.available2021-02-25T11:20:30Z
dc.date.issued2021-02
dc.description.abstractInflammatory bowel diseases (IBD) are characterized by a chronic inflammatory process that affects the intestinal barrier structure. Recent evidence suggests that some food components can influence the integrity of the intestinal barrier and thus its permeability. We aimed at assessing the effect of food components on intestinal permeability (IP) and on inflammatory markers in individuals with IBD by a single-blind randomized clinical study. Of the 53 individuals included, 47% (n = 25) had been diagnosed with IBD. The participants were divided into 4 groups. IBD patients were allocated to intervention group (n = 14) vs. no intervention group (n = 11), and the same happened with 28 control participants without disease (n = 14 in intervention group vs. n = 14 without intervention). Symptomatology, nutritional status, biochemical parameters (specifically serum zonulin (ZO) to measure IP) were evaluated on all individuals on an eight-week period following a diet plan with/without potentially beneficial foods for the IP. At the beginning of the study, there were no significant differences in ZO values between individuals with and without IBD (p > 0.05). The effect of specific food components was inconclusive; however, a trend in the reduction of inflammatory parameters and on the prevalence of gastrointestinal symptomatology was observed. More controlled intervention studies with diet plans, including food components potentially beneficial for the integrity of the intestinal barrier, are of the utmost importance.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationLacerda JF, Lagos AC, Carolino E, Silva-Herdade AS, Silva M, Guerreiro CS. Functional food components, intestinal permeability and inflammatory markers in patients with inflammatory bowel disease. Nutrients. 2021;13(2):642.pt_PT
dc.identifier.doi10.3390/nu13020642pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/12954
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relation.publisherversionhttps://www.mdpi.com/2072-6643/13/2/642pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectInflammatory bowel diseasept_PT
dc.subjectIntestinal permeabilitypt_PT
dc.subjectSerum zonulinpt_PT
dc.subjectInflammationpt_PT
dc.subjectFunctional foodspt_PT
dc.titleFunctional food components, intestinal permeability and inflammatory markers in patients with inflammatory bowel diseasept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue2pt_PT
oaire.citation.startPage642pt_PT
oaire.citation.titleNutrientspt_PT
oaire.citation.volume13pt_PT
person.familyNameCarolino
person.givenNameElisabete
person.identifier.ciencia-id1216-EFA3-1E0F
person.identifier.orcid0000-0003-4165-7052
person.identifier.ridF-1012-2015
person.identifier.scopus-author-id25821697000
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication77930d39-ed34-44dc-a4a6-9bf833e5e688
relation.isAuthorOfPublication.latestForDiscovery77930d39-ed34-44dc-a4a6-9bf833e5e688

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