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Advisor(s)
Abstract(s)
Project goals: Identification of novel agents with higher HbF inducing activity and lower cytotoxicity accessible in low-income countries, has been one of the major challenges over the past few years. A naturally occurring isoflavone found in plant products ( lentils, and chickpeas). Potent inhibitor of the PTK and topoisomerase II G 2 /M cell cycle arrest) regulates MAPK pathways (p 38 MAPK and ERK 1 /ERK 2. Antioxidant, antineoplastic, antihelmintic antiangiogenic, and immunosuppressive properties. Structurally similar to estrogen (estradiol 17 β). Potential to mimic, enhance, or impair the estradiol biosynthesis pathway with high reported binding selectivity for ER β isoform.
Description
IPL/2019/HemoFet_ESTeSL
Keywords
Genisteína Expressão do gene da γ-globulina Hemoglobina fetal IPL/2019/HemoFet_ESTeSL
Citation
Matos E, Sousa D, Delgadinho M, Mateus V, Silva IJ, Ribeiro E, Brito M. Potencial da genisteína na reativação da expressão do gene da γ-globulina e indução da hemoglobina fetal. In: III Congresso Nacional de Ciências Médicas Laboratoriais, ESTeSL, 25 a 27 de outubro de 2019.