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Potencial da genisteína na reativação da expressão do gene da γ-globulina e indução da hemoglobina fetal

2019-10Conference object Open access
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dc.contributor.authorMatos, Elisabete
dc.contributor.authorSousa, Daniela
dc.contributor.authorDelgadinho, Mariana
dc.contributor.authorMateus, Vanessa
dc.contributor.authorSilva, Inês
dc.contributor.authorRibeiro, Edna
dc.contributor.authorBrito, Miguel
dc.date.accessioned2021-02-27T17:57:57Z
dc.date.available2021-02-27T17:57:57Z
dc.date.issued2019-10
dc.descriptionIPL/2019/HemoFet_ESTeSLpt_PT
dc.description.abstractProject goals: Identification of novel agents with higher HbF inducing activity and lower cytotoxicity accessible in low-income countries, has been one of the major challenges over the past few years. A naturally occurring isoflavone found in plant products ( lentils, and chickpeas). Potent inhibitor of the PTK and topoisomerase II G 2 /M cell cycle arrest) regulates MAPK pathways (p 38 MAPK and ERK 1 /ERK 2. Antioxidant, antineoplastic, antihelmintic antiangiogenic, and immunosuppressive properties. Structurally similar to estrogen (estradiol 17 β). Potential to mimic, enhance, or impair the estradiol biosynthesis pathway with high reported binding selectivity for ER β isoform.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMatos E, Sousa D, Delgadinho M, Mateus V, Silva IJ, Ribeiro E, Brito M. Potencial da genisteína na reativação da expressão do gene da γ-globulina e indução da hemoglobina fetal. In: III Congresso Nacional de Ciências Médicas Laboratoriais, ESTeSL, 25 a 27 de outubro de 2019.pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/12990
dc.language.isoporpt_PT
dc.peerreviewedyespt_PT
dc.relationIPL/2019/HemoFet_ESTeSLpt_PT
dc.relation.publisherversionhttps://www.estesl.ipl.pt/agenda/iii-congresso-nacional-de-ciencias-biomedicas-laboratoriaispt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectGenisteínapt_PT
dc.subjectExpressão do gene da γ-globulinapt_PT
dc.subjectHemoglobina fetalpt_PT
dc.subjectIPL/2019/HemoFet_ESTeSLpt_PT
dc.titlePotencial da genisteína na reativação da expressão do gene da γ-globulina e indução da hemoglobina fetalpt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.citation.conferencePlaceLisboapt_PT
person.familyNamePinho Mateus
person.familyNameda Silva
person.familyNameRibeiro
person.familyNameBrito
person.givenNameVanessa Alexandra
person.givenNameInês Filipa Janeiro da Silva
person.givenNameEdna
person.givenNameMiguel
person.identifier.ciencia-id5A12-571D-AD6A
person.identifier.ciencia-idC010-323F-3266
person.identifier.ciencia-idC414-CDF2-D35A
person.identifier.ciencia-id231F-F341-7E93
person.identifier.orcid0000-0002-3204-3772
person.identifier.orcid0000-0001-7049-2512
person.identifier.orcid0000-0003-1316-7750
person.identifier.orcid0000-0001-6394-658X
person.identifier.ridA-7970-2016
person.identifier.scopus-author-id35224551000
rcaap.rightsopenAccesspt_PT
rcaap.typeconferenceObjectpt_PT
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relation.isAuthorOfPublication995e1831-ff5b-49e7-a6e3-8bc692212204
relation.isAuthorOfPublicationa571bf34-bcda-49ca-b5cb-4cdecbb3d9c7
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relation.isAuthorOfPublication.latestForDiscoverya571bf34-bcda-49ca-b5cb-4cdecbb3d9c7

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