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Orientador(es)
Resumo(s)
Epigallocatechin-3-gallate (EGCG), the major catechin present in green tea, displays diverse biological activities as anti-oxidation, anti-inflammation, anti-proliferation and anti-microbial among others. In the present work, it was evaluated the effect of the consumption of EGCG along 90 days on healthy human volunteers (n=30) on plasma molecular signature acquired by mid-infrared (MIR) spectroscopy. It was observed by principal component analysis of spectra that plasma samples presented a significantly different molecular profile after 90 days of EGCG consumption. Based on the corresponding loading vector, it was observed that EGCG consumption affected the profile of the major molecules like proteins and lipids. Were identified diverse ratios of spectral bands statistically different (p<0.01) after EGCG consumption, according to a high impact of EGCG on the general metabolism. MIR spectroscopy enabled to acquire the plasma whole molecular signature in a highly sensitive and specific mode. Since the MIR spectra are also acquired in an economical, simple, fast and high-throughput mode, the technique presents promising characteristics to acquire information in large-scale epidemiological studies towards a better understanding of the in vivo effect of EGCG.
Descrição
Palavras-chave
Epigallocatechin Green tea Metabolomics Polyphenols Epigallocatechin-3-gallate Mid-infrared spectroscopy
Contexto Educativo
Citação
Araújo RA, Ramalhete LM, Ribeiro E, Calado CR. Effect of consumption of green tea extracts on the plasma molecular signature. In: ENBENG 2019 – Proceedings of the 6th IEEE Portuguese Meeting on Bioengineering, Instituto Superior de Engenharia de Lisboa (ISEL), Portugal, February 22-23, 2019. Article no. 8692524.
Editora
IEEE