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Effect of consumption of green tea extracts on the plasma molecular signature

2019-04Journal article Restricted access
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dc.contributor.authorAraujo, Ruben A. D.
dc.contributor.authorRamalhete, Luis M.
dc.contributor.authorRibeiro, Edna
dc.contributor.authorCalado, Cecilia R. C.
dc.date.accessioned2019-05-27T15:50:26Z
dc.date.available2019-05-27T15:50:26Z
dc.date.issued2019-04
dc.description.abstractEpigallocatechin-3-gallate (EGCG), the major catechin present in green tea, displays diverse biological activities as anti-oxidation, anti-inflammation, anti-proliferation and anti-microbial among others. In the present work, it was evaluated the effect of the consumption of EGCG along 90 days on healthy human volunteers (n=30) on plasma molecular signature acquired by mid-infrared (MIR) spectroscopy. It was observed by principal component analysis of spectra that plasma samples presented a significantly different molecular profile after 90 days of EGCG consumption. Based on the corresponding loading vector, it was observed that EGCG consumption affected the profile of the major molecules like proteins and lipids. Were identified diverse ratios of spectral bands statistically different (p<0.01) after EGCG consumption, according to a high impact of EGCG on the general metabolism. MIR spectroscopy enabled to acquire the plasma whole molecular signature in a highly sensitive and specific mode. Since the MIR spectra are also acquired in an economical, simple, fast and high-throughput mode, the technique presents promising characteristics to acquire information in large-scale epidemiological studies towards a better understanding of the in vivo effect of EGCG.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationAraújo RA, Ramalhete LM, Ribeiro E, Calado CR. Effect of consumption of green tea extracts on the plasma molecular signature. In: ENBENG 2019 – Proceedings of the 6th IEEE Portuguese Meeting on Bioengineering, Instituto Superior de Engenharia de Lisboa (ISEL), Portugal, February 22-23, 2019. Article no. 8692524.pt_PT
dc.identifier.doi10.1109/ENBENG.2019.8692524pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/10074
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherIEEEpt_PT
dc.relation.publisherversionhttps://ieeexplore.ieee.org/document/8692524pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectEpigallocatechinpt_PT
dc.subjectGreen teapt_PT
dc.subjectMetabolomicspt_PT
dc.subjectPolyphenolspt_PT
dc.subjectEpigallocatechin-3-gallatept_PT
dc.subjectMid-infrared spectroscopypt_PT
dc.titleEffect of consumption of green tea extracts on the plasma molecular signaturept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage4pt_PT
oaire.citation.startPage1pt_PT
person.familyNameRibeiro
person.givenNameEdna
person.identifier.ciencia-idC414-CDF2-D35A
person.identifier.orcid0000-0003-1316-7750
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationa571bf34-bcda-49ca-b5cb-4cdecbb3d9c7
relation.isAuthorOfPublication.latestForDiscoverya571bf34-bcda-49ca-b5cb-4cdecbb3d9c7

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