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The impact of the ABO/Rh blood group on susceptibility and severity among COVID-19 patients in Luanda, Angola

2022-10Preprint Open access
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dc.contributor.authorSebastião, Cruz S.
dc.contributor.authorTeixeira, Alice
dc.contributor.authorLuísa, Ana
dc.contributor.authorArrais, Margarete
dc.contributor.authorTchonhi, Chissengo
dc.contributor.authorCogle, Adis
dc.contributor.authorSacomboio, Euclides
dc.contributor.authorCardoso, Bruno
dc.contributor.authorMorais, Joana
dc.contributor.authorVasconcelos, Jocelyne Neto de
dc.contributor.authorBrito, Miguel
dc.date.accessioned2022-10-25T11:19:55Z
dc.date.available2022-10-25T11:19:55Z
dc.date.issued2022-10
dc.description.abstractSARS-CoV-2 is a public health concern worldwide. Identification of biological factors that could influence transmission and worsen the disease has been the subject of extensive investigation. Herein, we investigate the impact of the ABO/Rh blood group on susceptibility and severity among COVID-19 patients in Luanda, Angola. This was a multicentric cohort study conducted with 101 COVID-19 patients. Chi-square and logistic regression were calculated to check factors related to the worsening of the disease and deemed significant when p<0.05. Blood type O (51.5%) and Rh-positive (93.1%) were the most frequent. Patients from blood type O had a high risk to severe disease [OR: 1.33 (95% CI: 0.42 - 4.18), p=0.630] and hospitalization [OR: 2.59 (95% CI: 0.84 - 8.00), p=0.099]. Also, Rh-positive blood type presented a high risk for severe disease (OR: 10.6, p=0.007) and hospitalization (OR: 6.04, p=0.026). We find a high susceptibility, severity, hospitalization, and mortality, respectively, among blood group O and Rh-positive patients, while blood group AB presented a low susceptibility, severity, hospitalization, and mortality, respectively. Our findings add to the body of evidence suggesting that ABO/Rh blood groups play an important role in the course of SARS-CoV-2 infection.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSebastião CS, Teixeira A, Luísa A, Arrais M, Tchonhi C, Brito M, et al. The impact of the ABO/Rh blood group on susceptibility and severity among COVID-19 patients in Luanda, Angola. In: BioRxiv. 2022 October 17 [preprint].pt_PT
dc.identifier.doi10.1101/2022.10.14.512325pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/15041
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relation.publisherversionhttps://www.biorxiv.org/content/10.1101/2022.10.14.512325v1pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectCOVID-19pt_PT
dc.subjectSARS-CoV-2pt_PT
dc.subjectBlood groupspt_PT
dc.subjectABO/Rhpt_PT
dc.subjectDisease severitypt_PT
dc.subjectAngolapt_PT
dc.subjectLuandapt_PT
dc.titleThe impact of the ABO/Rh blood group on susceptibility and severity among COVID-19 patients in Luanda, Angolapt_PT
dc.typepreprint
dspace.entity.typePublication
oaire.citation.titleBioRxivpt_PT
person.familyNameBrito
person.givenNameMiguel
person.identifier.ciencia-id231F-F341-7E93
person.identifier.orcid0000-0001-6394-658X
person.identifier.ridA-7970-2016
person.identifier.scopus-author-id35224551000
rcaap.rightsopenAccesspt_PT
rcaap.typepreprintpt_PT
relation.isAuthorOfPublication4252d8e0-800c-4d67-8b13-0b711d860669
relation.isAuthorOfPublication.latestForDiscovery4252d8e0-800c-4d67-8b13-0b711d860669

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