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A mixture design with nanoplastics and bisphenol A: cytotoxicity and genotoxicity assessment

2024-09Póster em conferência Acesso aberto
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datacite.subject.sdg03:Saúde de Qualidade
dc.contributor.authorBrito, Cláudia
dc.contributor.authorRibeiro, Edna
dc.contributor.authorMarques-Ramos, Ana
dc.contributor.authorMendes, Luís
dc.contributor.authorLadeira, Carina
dc.date.accessioned2025-04-08T17:29:07Z
dc.date.available2025-04-08T17:29:07Z
dc.date.issued2024-09
dc.descriptionThis work was supported by the project PLASCOGEN (IPL/2021/PLASCOGEN_ESTeSL). H&TRC authors gratefully acknowledge the FCT/MCTES national support through the UIDB/05608/2020 and UIDP/05608/2020.
dc.description.abstractThe widespread circulation of nanoplastics (NPs) and bisphenols (BPs) in Methods the environment, inevitably results in complex interactions and associated detrimental effects, which have the potential to reach the human body by multiple routes. Considering the levels of plastic oral exposure via ingestion and the absorption of these substances in gastric tissues, NPs endorse hazardous potential given the evidence of toxic effects on a cellular level. Furthermore, the ability to act as a vector for other pollutants and its ability to be internalized by cells potentiate long-term effects. Bisphenol A (BPA) is a xenoestrogen, that exhibits hormone-like properties that mimic the effects of estrogen in the body and is widely used in consumer products. The aim of this in vitro study was to investigate the cytotoxicity and genotoxicity of polystyrene (PS)-NPs and BPA per se and in combined exposures on the gastric GP202 cell line. For that, environmentally relevant concentrations previously tested in literature were selected, for PS-NPs - 20, 100, and 200 μg/mL and BPA - 0.1, 1 ng/mL, and 0.04 ng/mL as the new reference value proposed by EFSA.eng
dc.identifier.citationBrito C, Ribeiro E, Ramos A, Mendes L, Ladeira C. A mixture design with nanoplastics and bisphenol A: cytotoxicity and genotoxicity assessment. In: 52nd Congress of the European Environmental Mutagenesis and Genomics Society (EEMGS), Rovinj (Croatia), September 23-27, 2024.
dc.identifier.urihttp://hdl.handle.net/10400.21/21789
dc.language.isoeng
dc.peerreviewedyes
dc.relationIPL/2021/PLASCOGEN_ESTeSL
dc.relation.hasversionhttps://eemgs.eu/news-new/52nd-eemgs-icaw-meeting-2024/
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectPolystyrene
dc.subjectCytotoxicity
dc.subjectGenotoxicity
dc.subjectOccupational exposure
dc.subjectFCT_UIDB/05608/2020
dc.subjectFCT_UIDP/05608/2020
dc.subjectIPL/2021/PLASCOGEN_ESTeSL
dc.titleA mixture design with nanoplastics and bisphenol A: cytotoxicity and genotoxicity assessmenteng
dc.typeconference poster
dspace.entity.typePublication
oaire.citation.conferenceDate2024-09
oaire.citation.conferencePlaceRovinj, Croácia
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameRibeiro
person.familyNameMarques-Ramos
person.familyNameLadeira
person.givenNameEdna
person.givenNameAna
person.givenNameCarina
person.identifier144237
person.identifier.ciencia-idC414-CDF2-D35A
person.identifier.ciencia-id0617-3550-881E
person.identifier.ciencia-id801C-1BBA-1D9E
person.identifier.orcid0000-0003-1316-7750
person.identifier.orcid0000-0003-2655-8806
person.identifier.orcid0000-0001-5588-0074
person.identifier.ridJ-2572-2012
person.identifier.scopus-author-id36463788000
relation.isAuthorOfPublicationa571bf34-bcda-49ca-b5cb-4cdecbb3d9c7
relation.isAuthorOfPublication0b8d516d-bf23-4db0-8224-d33e28d309ac
relation.isAuthorOfPublication1aef4b60-4197-436b-84ab-80d31cbaed33
relation.isAuthorOfPublication.latestForDiscovery1aef4b60-4197-436b-84ab-80d31cbaed33

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