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Advisor(s)
Abstract(s)
As alterações climáticas têm sido identificadas como um fator determinante para a segurança dos alimentos consumidos em todo o mundo. As micotoxinas, contaminantes alimentares produzidos por fungos, são habitualmente identificadas como um dos principais perigos neste contexto. As aflatoxinas assumem particular relevo, face à sua toxicidade aguda e crónica. A região do Mediterrâneo, incluindo Portugal, tem sido considerada uma região particularmente vulnerável às consequências das alterações climáticas. O presente estudo pretende estimar o impacto na saúde da exposição a aflatoxinas em Portugal e discutir a potencial influência das alterações climáticas no risco para a saúde associado a esta exposição. Para estimar o número de casos de carcinoma hepatocelular associados à exposição a aflatoxinas, foi determinada a fração atribuível da população. Para estimar o impacto da exposição a aflatoxinas na saúde dos Portugueses, a carga de doença foi determinada aplicando-se o conceito de anos de vida ajustados por incapacidade (DALY). É expectável que no futuro, em consequência das alterações climáticas, o número de DALYs bem como do número de casos de carcinoma hepatocelular aumente. A quantificação do impacto na saúde da exposição a aflatoxinas em cenário de alterações climáticas reveste-se de particular importância, em especial para o desenvolvimento de políticas e medidas preventivas que possam proteger a população.
ABSTRACT - Climate change has been indicated as a driver for food safety issues worldwide, mainly due to the impact on the occurrence of food safety hazards at various stages of the food chain. Mycotoxins, natural contaminants produced by fungi, are among the most important of such hazards. Aflatoxins, which have the highest acute and chronic toxicity of all mycotoxins, assume particular importance. Mediterranean region, including Portugal, was considered a climate change hotspot. The present study aims to estimate the health impact of aflatoxins exposure in Portugal and to discuss the potential influence of climate change on the health risk associated with this exposure. A population attributable fraction was determined to estimate the number of extra cases of hepatocellular carcinoma (HCC) associated with the Portuguese aflatoxin exposure, and the Disability Adjusted Life Years (DALYs) were derived to estimate the associated burden of disease. It is expected that in the future the number of DALYs and the associated cases of HCC due to aflatoxins exposure will increase due to climate change. The quantification of the health impact associated with exposure to aflatoxins in climate change scenarios presents particular importance, especially for the development of politics and preventive measures to protect the human population.
ABSTRACT - Climate change has been indicated as a driver for food safety issues worldwide, mainly due to the impact on the occurrence of food safety hazards at various stages of the food chain. Mycotoxins, natural contaminants produced by fungi, are among the most important of such hazards. Aflatoxins, which have the highest acute and chronic toxicity of all mycotoxins, assume particular importance. Mediterranean region, including Portugal, was considered a climate change hotspot. The present study aims to estimate the health impact of aflatoxins exposure in Portugal and to discuss the potential influence of climate change on the health risk associated with this exposure. A population attributable fraction was determined to estimate the number of extra cases of hepatocellular carcinoma (HCC) associated with the Portuguese aflatoxin exposure, and the Disability Adjusted Life Years (DALYs) were derived to estimate the associated burden of disease. It is expected that in the future the number of DALYs and the associated cases of HCC due to aflatoxins exposure will increase due to climate change. The quantification of the health impact associated with exposure to aflatoxins in climate change scenarios presents particular importance, especially for the development of politics and preventive measures to protect the human population.
Description
Keywords
Saúde ocupacional Exposição ocupacional Alterações climáticas Aflatoxinas Portugal Occupational health Occupational exposure Climate change Aflatoxin
Citation
Assunção R, Martins C, Viegas S, Viegas C, Jakobsen LE, Pires SM, et al. Impacto das alterações climáticas na exposição da população portuguesa a aflatoxinas. Observações Bol Epidemiol. 2018;(22):25-8.