Browsing by resource type "conference poster"
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- Adverse events related to etonogestrel implant: an old but still current issue?Publication . Fernandes, João Paulo; Silva, Marcia; Sousa, Margarida; Bhikha, Jani; Moreira, Paula; Silva, IsabelIntroduction: In December 2019, in Portugal, a Direct Healthcare Professional Communication (DHPC) was approved regarding the subcutaneous implant of etonogestrel 68 mg. The genesis of this communication was based on reported cases of neurovascular injury and migration of the implant from the insertion site within the arm, or, in rare cases, into the pulmonary artery, possibly associated with deep or incorrect implant insertion. To minimize risks, the DHPC has introduced updates to the instructions for the insertion and removal of the implant. Aim/Objective: Our work aims to conduct a descriptive analysis of the number of Individual Case Safety Reports (ICSRs) received by the Portuguese National Pharmacovigilance System (SNF) following the DHPC, related to adverse events associated with the insertion and removal of the etonogestrel implant.
- Análise do complexo de células ganglionares maculares na detecção precoce do glaucomaPublication . Pineza, Cátia; Fernandes, Nádia; Araújo, MartaO Glaucoma é uma neuropatia óptica multifactorial caracterizada pela perda de Células Ganglionares Retinianas (CGR) com consequente perda de fibras nervosas retinianas resultando numa limitação visual. O Complexo de Células Ganglionares (CCG) é constituído pelas 3 camadas mais internas da retina: Camada de Fibras Nervosas (CFNR), a Camada de Células Ganglionares (GCL) e a Camada Plexiforme Interna (IPL). Estudos realizados por Tan et al sugerem que no Glaucoma estas camadas são preferencialmente afectadas comparativamente às restantes camadas da mácula, uma vez que contêm os axónios, o corpo e as dendrites das mesmas. Esta teoria é fundamentada por estudos clínicos que defendem que não existe perda de fotorreceptores no Glaucoma. A região macular contém mais de 50% de CGR, desta forma será uma zona preferencial para o estudo e detecção atempada da perda das mesmas. Ahmad (2011) refere que a perda dos axónios das CGR resulta na diminuição da espessura do Nervo Óptico (NO) e da CFNR. Lesões nos axónios das CGR causam perdas no número de células, particularmente na mácula, resultando numa diminuição da espessura da GCL. Muitos estudos têm demonstrado que a eficácia das medições do NO e das estruturas retinianas podem permitir a distinção entre olhos normais e olhos glaucomatosos.
- Assessment of DNA damage and oxidative stress of green tea epigallocatechin-3-gallate (EGCG) by comet assayPublication . Ladeira, Carina; Ramos, Carina; Pádua, Mário; Ribeiro, EdnaIntroduction: EGCG, the primary polyphenol in green tea, has been shown to inhibit cancer cell growth and tumorigenesis in vitro and animal models, particularly by eliminating cancer cells through induction of apoptosis and protecting normal cells against genotoxic hazards. However, increasing evidence indicates that EGCG produces ROS. Aim of the study: Evaluate DNA damage and oxidative damage, measured by comet assay; lipid profile, liver function parameters, and vitamins A and E levels during an interventional study with 90 days (T0 and T90) duration (T0 and T90) in 30 individuals with an EGCG intake of 225 mg/day.
- Carcinossarcoma: estudo de caso em citologia ginecológicaPublication . Pinheiro, Carla; Bento, Ana; Freitas, Bárbara; Roque, Ruben; André, Saudade; Mendonça, PaulaO carcinossarcoma uterino, também conhecido por tumor mülleriano misto maligno, é um tumor raro em mulheres e tem um comportamento clínico agressivo. Corresponde a menos de 5% dos tumores malignos do corpo uterino, mas é responsável por 15-30% dos casos de morte em doentes com neoplasia maligna do útero. É uma neoplasia maligna bifásica caracterizada, histologicamente, por ser constituída por componente epitelial e mesenquimatosa. A literatura sugere que a componente epitelial é determinante na agressividade tumoral, sustentando a classificação como carcinoma do endométrio de alto grau. A componente mesenquimatosa divide-se em homóloga (quando é semelhante às células encontradas no órgão de origem) ou heteróloga. Em alguns casos não são identificáveis as duas componentes na amostra citológica, sendo por isso um tipo de tumor difícil de distinguir em citopatologia. Os fatores de risco são idade avançada, raça negra, nuliparidade com co-morbilidades (obesidade, diabetes, hipertensão arterial), uso de estrogénio exógeno e história de radioterapia pélvica. É uma neoplasia geralmente diagnosticada em estádios avançados e apresenta uma elevada taxa de progressão/recidiva nas doentes. O objetivo deste estudo é apresentar um caso de carcinossarcoma em citologia ginecológica, evidenciando as características citomorfológicas que permitem identificar esta neoplasia.
- Choroidal and retinal imaging biomarkers in age-related macular degeneration and vitamin D supplementation: a reviewPublication . Fernandes, Nádia; Araújo, Marta; Lança, Carla; Carvalho, TiagoAge-related Macular Degeneration (AMD) is a chronic and multifactorial aging retinal disease that causes irreversible central vision loss. In Europe, AMD represents the main cause of severe visual impairment and blindness in the elderly. Health status, low antioxidant diet, and sedentary lifestyles are modifiable risk factors. Health promotion and preventive medicine are essential to reduce the risk of disease progression and visual impairment. Vitamin D [25(OH)D] (Vit D) deficiency may be a risk factor for AMD. The anti-inflammatory potential of Vit D in AMD and its contribution to improving retinal antioxidant protection has been investigated. A systematic review and meta-analysis conducted by Ferreira et al. showed there was a trend for advanced AMD in people with serum Vit D<50nmol/L. Thus, increasing 25(OH)D levels through dietary intake and supplementation may be beneficial. A structural evaluation using SD-OCT and OCT-A seems to be an interesting tool for assessing changes in the retina and choroid after supplementation.
- Choroidal metastasis vs choroidal nevus - EDI OCT findings: case reportsPublication . Carvalho, Tiago; Fernandes, NádiaEnhanced depth imaging optical coherence tomography (EDI-OCT) is a novel imaging modality that has helped retina specialists learn more about the choroid’s role in the eye. As a health professional who develops teamwork with specialists, an orthoptist must know about the higher-resolution images and improved imaging acquisition of lesions that EDI-OCT provides. This poster summarizes the EDI-OCT findings between two clinical entities: choroidal metastasis and choroidal nevus.
- Comparação entre a parafina e a cera de abelha na impregnação e inclusão da técnica histológicaPublication . Alves, Joana; Almeida, Rita; Palma, João; Ladeira, CarinaA parafina é o meio de impregnação e inclusão de eleição devido às suas características inerentes e baixo custo, no entanto é uma substância que apresenta problemas ambientais e técnicos. Na tentativa de combater estas lacunas, e tendo em conta os resultados obtidos por Antony et al em tecidos orais e as suas semelhanças com a parafina, a cera de abelha surge como uma alternativa promissora. Objetivo do estudo: Substituir a parafina por cera de abelha, como meio de impregnação e inclusão.
- Concerns about the reuse of waste water: effects of mixtures of chemical substances on human healthPublication . Cabêda, José; Ladeira, CarinaDue to global warming, the future trend is to adopt good practices in the use of treated wastewater in agriculture, industry, and the urban sector, with particular emphasis on arid and sub-arid regions. In the European context, the Southern Mediterranean countries are the most vulnerable and the costs of inaction are significant. The regulation approved on 13 May 2020 by the European Parliament establishes minimum requirements for the reuse of treated urban wastewater, to guarantee an alternative water supply. These requirements mainly concern water quality and monitoring, and some member states, such as Portugal, have requirements for water reuse in legislation or non-regulatory national standards.
- Cutaneous non-tuberculous mycobacteria infection: a case report and literature reviewPublication . Fialho, M. Pinto; Carvalho, M. M.; Catarino, A. M.; Casanova, S. R.; Sampaio, R.Background & objectives: Non-tuberculous mycobacteria (NTM) are often overlooked as opportunistic agents causing cutaneous infections. While histological findings may resemble cutaneous tuberculosis, treatment and clinical management differ significantly. We present a case of NTM skin infection and a literature review. Methods: A 62-year-old female with autoimmune hepatitis, on immunosuppression, received a corticosteroid injection in the elbow joint. Six months later, she presented with a skin nodule at the injection site, histologically diagnosed as cutaneous tuberculosis. Despite being asymptomatic and lacking epidemiological context or chest X-ray abnormalities, a second adjacent skin nodule developed and was subsequently biopsied. Results: The skin biopsies showed poorly formed epithelioid nonnecrotizing granulomas with neutrophilic microabscesses (suppurative granulomas) and Langhans-type multinucleated giant cells in the reticular dermis and subcutaneous tissue. Gram and Grocott stains were negative, and acid-alcohol-resistant bacilli were observed using the Ziehl-Neelsen stain. As suggested by Song et al., we identified small vessel proliferation with sparse fibroblasts within the lesions. The histological examinations were consistent with NTM skin infection and confirmed by polymerase chain reaction (PCR). Conclusion: The case underscores the diagnostic challenge posed by NTM infections, often mimicking cutaneous tuberculosis. These histopathological findings should help pathologists decide when to suspect an NTM infection, avoiding a delay in diagnosis and a tuberculosis label that could lead to overtest and unnecessary treatments.
- Establishing standard operating procedures for isolation, characterizing and preservation of cells from oral potentially malignant disorders: a concept project proposalPublication . Costea, Daniela Elena; Ladeira, Carina; Vandis, Vera; Kozlakidis, ZisisStandard operating procedures (SOP) are crucial for the isolation, characterization, and biobanking of cells from tissues due to several key reasons: consistency and reproducibility, quality control, data integrity and Traceability, safety and ethics, resource efficiency, cross-training and knowledge transfer, regulatory compliance, publication and collaboration, and long-term research. This project aims to establish standard operating procedures (SOP) for isolating, characterizing, and biobanking cells from oral potentially malignant disorders (OPMDs).