Browsing by Author "Pires, Sara M."
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- Burden of disease attributable to risk factors in European countries: a scoping literature reviewPublication . Gorasso, Vanessa; Morgado, Joana Nazaré; Charalampous, Periklis; Pires, Sara M.; Haagsma, Juanita A.; Santos, João Vasco; Idavain, Jane; Ngwa, Che Henry; Noguer, Isabel; Padron-Monedero, Alicia; Sarmiento, Rodrigo; Pinheiro, Vera; Von der Lippe, Elena; Jakobsen, Lea Sletting; Devleesschauwer, Brecht; Plass, Dietrich; Aasvang, Gunn Marit; Ádám, Balázs; Alkerwi, Ala’a; Arabloo, Jalal; Baltazar, Ana Lúcia; Uysal, Hilal Bektas; Bikbov, Boris; Bolling, Anette Kocbach; Borrell-Pages, Maria; Carreras, Giulia; Castelpietra, Giulio; Chen-Xu, José; Lagarija, Šeila Cilović; Corso, Barbara; Cuschieri, Sarah; De Pauw, Robby; Dhaouadi, Sonia; Dokova, Klara; Dopelt, Keren; Economou, Mary; Emeto, Theophilus I.; Fantke, Peter; Fischer, Florian; Freitas, Alberto; Galluzzo, Lucia; García-González, Juan Manuel; Gazzelloni, Federica; Gissler, Mika; Gkitakou, Artemis; Gubes, Sezgin; Canu, Irina Guseva; Hincapié, Cesar A.; Hynds, Paul; Ilic, Irena; Ilic, Milena; Isola, Gaetano; Kabir, Zubair; Kolkhir, Pavel; Konar, Naime Meriç; Kretzschmar, Mirjam; Kulimbet, Mukhtar; La Vecchia, Carlo; Ladeira, Carina; Lassen, Brian; Lauriola, Paolo; Lehtomäki, Heli; Levi, Miriam; Majer, Marjeta; McDonald, Scott A.; Mechili, Enkeleint A.; Misins, Janis; Monasta, Lorenzo; Laguna, Javier Muñoz; Namorado, Sónia; Nena, Evangelia; Ng, Edmond S. W.; Nguewa, Paul; Niranjan, Vikram; Nola, Iskra Alexandra; Obradović, Marija; O’Caoimh, Rónán; Öztürk, Nazife; Pastorinho, M. Ramiro; Petrou, Panagiotis; Peyroteo, Mariana; Ortiz, Miguel Reina; Riva, Silvia; Rocha-Gomes, João; Santoso, Cornelia Melinda Adi; Schmitt, Tugce; Shigdel, Rajesh; Sigurvinsdottir, Rannveig; Soriano, Joan B.; Sousa, Ana Catarina; Sprügel, Maximilian; Steiropoulos, Paschalis; Tozija, Fimka; Unim, Brigid; Vandeninden, Bram; Varga, Orsolya; Vasic, Milena; Viegas, Susana; Vieira, Rafael; Violante, Francesco S.; Wyper, Grant M. A.; Yigit, Vahit; Zaletel, JelkaObjectives: Within the framework of the burden of disease (BoD) approach, disease, and injury burden estimates attributable to risk factors are a useful guide for policy formulation and priority setting in disease prevention. Considering the important differences in methods, and their impact on burden estimates, we conducted a scoping literature review to: (1) map the BoD assessments including risk factors performed across Europe, and (2) identify the methodological choices in comparative risk assessment (CRA) and risk assessment methods. Methods: We searched multiple literature databases, including grey literature websites, and targeted public health agencies' websites. Results: A total of 113 studies were included in the synthesis and further divided into independent BoD assessments (54 studies) and studies linked to the Global Burden of Disease (59 papers). Our results showed that the methods used to perform CRA varied substantially across independent European BoD studies. While there were some methodological choices that were more common than others, we did not observe patterns in terms of country, year, or risk factor. Each methodological choice can affect the comparability of estimates between and within countries and/or risk factors since they might significantly influence the quantification of the attributable burden. From our analysis, we observed that the use of CRA was less common for some types of risk factors and outcomes. These included environmental and occupational risk factors, which are more likely to use bottom-up approaches for health outcomes where disease envelopes may not be available. Conclusions: Our review also highlighted misreporting, the lack of uncertainty analysis, and the under-investigation of causal relationships in BoD studies. Development and use of guidelines for performing and reporting BoD studies will help understand differences, and avoid misinterpretations thus improving comparability among estimates.
- Impacto das alterações climáticas na exposição da população portuguesa a aflatoxinasPublication . Assunção, Ricardo; Martins, Carla; Viegas, Susana; Viegas, Carla; Jakobsen, Lea E.; Pires, Sara M.; Alvito, PaulaAs alterações climáticas têm sido identificadas como um fator determinante para a segurança dos alimentos consumidos em todo o mundo. As micotoxinas, contaminantes alimentares produzidos por fungos, são habitualmente identificadas como um dos principais perigos neste contexto. As aflatoxinas assumem particular relevo, face à sua toxicidade aguda e crónica. A região do Mediterrâneo, incluindo Portugal, tem sido considerada uma região particularmente vulnerável às consequências das alterações climáticas. O presente estudo pretende estimar o impacto na saúde da exposição a aflatoxinas em Portugal e discutir a potencial influência das alterações climáticas no risco para a saúde associado a esta exposição. Para estimar o número de casos de carcinoma hepatocelular associados à exposição a aflatoxinas, foi determinada a fração atribuível da população. Para estimar o impacto da exposição a aflatoxinas na saúde dos Portugueses, a carga de doença foi determinada aplicando-se o conceito de anos de vida ajustados por incapacidade (DALY). É expectável que no futuro, em consequência das alterações climáticas, o número de DALYs bem como do número de casos de carcinoma hepatocelular aumente. A quantificação do impacto na saúde da exposição a aflatoxinas em cenário de alterações climáticas reveste-se de particular importância, em especial para o desenvolvimento de políticas e medidas preventivas que possam proteger a população.
- Methodological considerations in injury burden of disease studies across Europe: a systematic literature reviewPublication . Charalampous, Periklis; Pallari, Elena; Gorasso, Vanessa; von der Lippe, Elena; Devleesschauwer, Brecht; Pires, Sara M.; Plass, Dietrich; Idavain, Jane; Ngwa, Che Henry; Noguer, Isabel; Padron-Monedero, Alicia; Sarmiento, Rodrigo; Majdan, Marek; Ádám, Balázs; AlKerwi, Ala’a; Cilovic-Lagarija, Seila; Clarsen, Benjamin; Corso, Barbara; Cuschieri, Sarah; Dopelt, Keren; Economou, Mary; Fischer, Florian; Freitas, Alberto; García-González, Juan Manuel; Gazzelloni, Federica; Gkitakou, Artemis; Gulmez, Hakan; Hynds, Paul; Isola, Gaetano; Jakobsen, Lea S.; Kabir, Zubair; Kissimova-Skarbek, Katarzyna; Knudsen, Ann Kristin; Konar, Naime Meriç; Ladeira, Carina; Lassen, Brian; Liew, Aaron; Majer, Marjeta; Mechili, Enkeleint A.; Mereke, Alibek; Monasta, Lorenzo; Mondello, Stefania; Morgado, Joana Nazaré; Nena, Evangelia; Ng, Edmond S. W.; Niranjan, Vikram; Nola, Iskra Alexandra; O’Caoimh, Rónán; Petrou, Panagiotis; Pinheiro, Vera; Ortiz, Miguel Reina; Riva, Silvia; Samouda, Hanen; Santos, João Vasco; Santoso, Cornelia Melinda Adi; Milicevic, Milena Santric; Skempes, Dimitrios; Sousa, Ana Catarina; Speybroeck, Niko; Tozija, Fimka; Unim, Brigid; Uysal, Hilal Bektaş; Vaccaro, Fabrizio Giovanni; Varga, Orsolya; Vasic, Milena; Violante, Francesco Saverio; Wyper, Grant M. A.; Polinder, Suzanne; Haagsma, Juanita A.Background: Calculating the disease burden due to injury is complex, as it requires many methodological choices. Until now, an overview of the methodological design choices that have been made in the burden of disease (BoD) studies in injury populations is not available. The aim of this systematic literature review was to identify existing injury BoD studies undertaken across Europe and to comprehensively review the methodological design choices and assumption parameters that have been made to calculate years of life lost (YLL) and years lived with disability (YLD) in these studies. Methods: We searched EMBASE, MEDLINE, Cochrane Central, Google Scholar, Web of Science, and the grey literature supplemented by hand-searching, for BoD studies. We included injury BoD studies that quantified the BoD expressed in YLL, YLD, and disability-adjusted life years (DALY) in countries within the European Region between early 1990 and mid-2021. Results: We retrieved 2,914 results of which 48 performed an injury-specific BoD assessment. Single-country independent and Global Burden of Disease (GBD)-linked injury BoD studies were performed in 11 European countries. Approximately 79% of injury BoD studies reported the BoD by external cause-of-injury. Most independent studies used the incidence-based approach to calculate YLDs. About half of the injury disease burden studies applied disability weights (DWs) developed by the GBD study. Almost all independent injury studies have determined YLL using national life tables. Conclusions: Considerable methodological variation across independent injury BoD assessments was observed; differences were mainly apparent in the design choices and assumption parameters towards injury YLD calculations, implementation of DWs, and the choice of a life table for YLL calculations. The development and use of guidelines for performing and reporting of injury BoD studies are crucial to enhance transparency and comparability of injury BoD estimates across Europe and beyond.
- Risks vs benefits of nuts consumption in Portugal: the balance between preventable myocardial infarctions and the burden of the liver cancer associated to aflatoxin exposurePublication . Assunção, Ricardo; Jakobsen, Lea S.; Alvito, Paula; Carmona, Paulo; Carvalho, Catarina; Lopes, Carla; Martins, Carla; Monteiro, Sarogini; Nabais, Pedro; Correia, Daniela; Torres, Duarte; Viegas, Carla; Viegas, Susana; Nauta, Maarten; Pires, Sara M.The occurrence of mycotoxins in nuts, including the most potent carcinogenic aflatoxins (AFTs), has been reported by several authors worldwide. Notwithstanding, nut consumption plays an important role in the Mediterranean diet due to their nutrient contents and the consequent potential to produce beneficial health effects, as the prevention of cardiovascular diseases. The present study aimed to quantify the health impact in terms of Disability-adjusted life years (DALY) of increasing nut consumption to 30g/day by adult Portuguese population when compared to the current intake.