Percorrer por autor "Fantke, Peter"
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- Building a European exposure science strategyPublication . Fantke, Peter; Von Goetz, Natalie; Schlüter, Urs; Bessems, Jos; Connolly, Alison; Dudzina, Tatsiana; Ahrens, Andreas; Bridges, Jim; Coggins, Marie A.; Conrad, André; Hänninen, Otto; Heinemeyer, Gerhard; Kephalopoulos, Stylianos; McLachlan, Michael; Meijster, Tim; Poulsen, Veronique; Rother, Dag; Vermeire, Theo; Viegas, Susana; Vlaanderen, Jelle; Jeddi, Maryam Zare; de Bruin, Yuri BruinenExposure information is a critical element in various regulatory and non-regulatory frameworks in Europe and elsewhere. Exposure science supports to ensure safe environments, reduce human health risks, and foster a sustainable future. However, increasing diversity in regulations and the lack of a professional identity as exposure scientists currently hamper developing the field and uptake into European policy. In response, we discuss trends and identify three key needs for advancing and harmonizing exposure science and its application in Europe. We provide overarching building blocks and define six long-term activities to address the identified key needs and to iteratively improve guidelines, tools, data, and education. More specifically, we propose creating European networks to maximize synergies with adjacent fields and identify funding opportunities, building common exposure assessment approaches across regulations, providing tiered education and training programs, developing an aligned and integrated exposure assessment framework, offering best practices guidance, and launching an exposure information exchange platform. Dedicated working groups will further specify these activities in a consistent action plan. Together, these elements form the foundation for establishing goals and an action roadmap for successfully developing and implementing a ‘European Exposure Science Strategy’ 2020–2030, which is aligned with advances in science and technology.
- Burden of disease attributable to risk factors in European countries: a scoping literature reviewPublication . Gorasso, Vanessa; Morgado, Joana Nazaré; Charalampous, Periklis; Pires, Sara M.; Haagsma, Juanita A.; Santos, João Vasco; Idavain, Jane; Ngwa, Che Henry; Noguer, Isabel; Padron-Monedero, Alicia; Sarmiento, Rodrigo; Pinheiro, Vera; Von der Lippe, Elena; Jakobsen, Lea Sletting; Devleesschauwer, Brecht; Plass, Dietrich; Aasvang, Gunn Marit; Ádám, Balázs; Alkerwi, Ala’a; Arabloo, Jalal; Baltazar, Ana Lúcia; Uysal, Hilal Bektas; Bikbov, Boris; Bolling, Anette Kocbach; Borrell-Pages, Maria; Carreras, Giulia; Castelpietra, Giulio; Chen-Xu, José; Lagarija, Šeila Cilović; Corso, Barbara; Cuschieri, Sarah; De Pauw, Robby; Dhaouadi, Sonia; Dokova, Klara; Dopelt, Keren; Economou, Mary; Emeto, Theophilus I.; Fantke, Peter; Fischer, Florian; Freitas, Alberto; Galluzzo, Lucia; García-González, Juan Manuel; Gazzelloni, Federica; Gissler, Mika; Gkitakou, Artemis; Gubes, Sezgin; Canu, Irina Guseva; Hincapié, Cesar A.; Hynds, Paul; Ilic, Irena; Ilic, Milena; Isola, Gaetano; Kabir, Zubair; Kolkhir, Pavel; Konar, Naime Meriç; Kretzschmar, Mirjam; Kulimbet, Mukhtar; La Vecchia, Carlo; Ladeira, Carina; Lassen, Brian; Lauriola, Paolo; Lehtomäki, Heli; Levi, Miriam; Majer, Marjeta; McDonald, Scott A.; Mechili, Enkeleint A.; Misins, Janis; Monasta, Lorenzo; Laguna, Javier Muñoz; Namorado, Sónia; Nena, Evangelia; Ng, Edmond S. W.; Nguewa, Paul; Niranjan, Vikram; Nola, Iskra Alexandra; Obradović, Marija; O’Caoimh, Rónán; Öztürk, Nazife; Pastorinho, M. Ramiro; Petrou, Panagiotis; Peyroteo, Mariana; Ortiz, Miguel Reina; Riva, Silvia; Rocha-Gomes, João; Santoso, Cornelia Melinda Adi; Schmitt, Tugce; Shigdel, Rajesh; Sigurvinsdottir, Rannveig; Soriano, Joan B.; Sousa, Ana Catarina; Sprügel, Maximilian; Steiropoulos, Paschalis; Tozija, Fimka; Unim, Brigid; Vandeninden, Bram; Varga, Orsolya; Vasic, Milena; Viegas, Susana; Vieira, Rafael; Violante, Francesco S.; Wyper, Grant M. A.; Yigit, Vahit; Zaletel, JelkaObjectives: Within the framework of the burden of disease (BoD) approach, disease, and injury burden estimates attributable to risk factors are a useful guide for policy formulation and priority setting in disease prevention. Considering the important differences in methods, and their impact on burden estimates, we conducted a scoping literature review to: (1) map the BoD assessments including risk factors performed across Europe, and (2) identify the methodological choices in comparative risk assessment (CRA) and risk assessment methods. Methods: We searched multiple literature databases, including grey literature websites, and targeted public health agencies' websites. Results: A total of 113 studies were included in the synthesis and further divided into independent BoD assessments (54 studies) and studies linked to the Global Burden of Disease (59 papers). Our results showed that the methods used to perform CRA varied substantially across independent European BoD studies. While there were some methodological choices that were more common than others, we did not observe patterns in terms of country, year, or risk factor. Each methodological choice can affect the comparability of estimates between and within countries and/or risk factors since they might significantly influence the quantification of the attributable burden. From our analysis, we observed that the use of CRA was less common for some types of risk factors and outcomes. These included environmental and occupational risk factors, which are more likely to use bottom-up approaches for health outcomes where disease envelopes may not be available. Conclusions: Our review also highlighted misreporting, the lack of uncertainty analysis, and the under-investigation of causal relationships in BoD studies. Development and use of guidelines for performing and reporting BoD studies will help understand differences, and avoid misinterpretations thus improving comparability among estimates.
- Developing human biomonitoring as a 21st century toolbox within the European Exposure Science Strategy 2022-2030Publication . Jeddi, Maryam Zare; Hopf, Nancy B.; Louro, Henriqueta; Viegas, Susana; Galea, Karen S.; Pasanen-Kase, Robert; Santonen, Tiina; Mustieles, Vicente; Fernandez, Mariana F.; Verhagen, Hans; Bopp, Stephanie K.; Philippe Antignac, Jean; David, Arthur; Mol, Hans; Barouki, Robert; Audouze, Karine; Duca, Radu-Corneliu; Fantke, Peter; Scheepers, Paul; Ghosh, Manosij; Van Nieuwenhuyse, An; Vicente, Joana Lobo; Trier, Xenia; Rambaud, Loïc; Fillol, Clémence; Denys, Sebastien; Conrad, André; Kolossa-Gehring, Marike; Paini, Alicia; Arnot, Jon; Schulze, Florian; Jones, Kate; Sepai, Ovnair; Ali, Imran; Brennan, Lorraine; Benfenati, Emilio; Cubadda, Francesco; Mantovani, Alberto; Bartonova, Alena; Connolly, Alison; Slobodnik, Jaroslav; de Bruin, Yuri Bruinen; van Klaveren, Jacob; Palmen, Nicole; Dirven, Hubert; Husøy, Trine; Thomsen, Cathrine; Virgolino, Ana; Röösli, Martin; Gant, Tim; von Goetz, Natalie; Bessems, JosHuman biomonitoring (HBM) is a crucial approach for exposure assessment, as emphasised in the European Commission’s Chemicals Strategy for Sustainability (CSS). HBM can help to improve chemical policies in five major key areas: (1) assessing internal and aggregate exposure in different target populations; 2) assessing exposure to chemicals across life stages; (3) assessing combined exposure to multiple chemicals (mixtures); (4) bridging regulatory silos on aggregate exposure; and (5) enhancing the effectiveness of risk management measures. In this strategy paper, we propose a vision and a strategy for the use of HBM in chemical regulations and public health policy in Europe and beyond. We outline six strategic objectives and a roadmap to further strengthen HBM approaches and increase their implementation in the regulatory risk assessment of chemicals to enhance our understanding of exposure and health impacts, enabling timely and targeted policy interventions and risk management. These strategic objectives are: 1) further development of sampling strategies and sample preparation; 2) further development of chemical-analytical HBM methods; 3) improving harmonisation throughout the HBM research life cycle; 4) further development of quality control/quality assurance throughout the HBM research life cycle; 5) obtain sustained funding and reinforcement by legislation; and 6) extend target-specific communication with scientists, policymakers, citizens and other stakeholders. HBM approaches are essential in risk assessment to address scientific, regulatory, and societal challenges. HBM requires full and strong support from the scientific and regulatory domain to reach its full potential in public and occupational health assessment and in regulatory decision-making.
- Framework for developing an exposure science curriculum as part of the European Exposure Science Strategy 2020-2030Publication . Connolly, Alison; Scheepers, Paul T.J.; Coggins, Marie A.; Vermeire, Theo; van Tongeren, Martie; Heinemeyer, Gerhard; Bridges, James W.; Bredendiek-Kämper, Susanne; de Bruin, Yuri Bruinen; Clayson, Anne; Gerding, Johannes; McCourt, Josephine; Urbanus, Jan; Viegas, Susana; von Goetz, Natalie; Zare-Jeddi, Maryam; Fantke, PeterBackground: Evaluating and managing exposures to chemical, physical, and biological stressors, which frequently interplay with psychological stressors as well as social and behavioural aspects, is crucial for protecting human and environmental health and transitioning towards a sustainable future. Advances in our understanding of exposure rely on input from well-trained exposure scientists. However, no education programmes in Europe are currently explicitly dedicated to covering the broader range of exposure science approaches, applications, stressors, and receptors. Objective: To address this challenge, a curriculum is needed that yields credible, well-defined career pathways in exposure science. Methods: Needs and conditions for advancing exposure to science education in Europe were identified. As a starting point for a way forward, harmonised learning outcomes for exposure science were defined at each level of the European Qualifications Framework. The course programme coordinators were recruited for three varying courses, with respect to the course level and the proportion of the curriculum dedicated to exposure science. These courses were assessed via our systematic course review procedure. Finally, strategic objectives and actions are proposed to build exposure science education programmes. Results: The ISES Europe ‘Education, Training and Communication’ expert working group developed a framework for creating a viable exposure science curriculum. Harmonised learning outcomes were structured under eight learning levels, categorised by knowledge, skills, and competence. Illustrative case studies demonstrated how education providers integrated these learning outcomes for their educational context and aligned the overall exposure science curriculum. Conclusions: The international recognition and adoption of exposure science education will enable advances in addressing global exposure science challenges for various stressors, from behavioural aspects from individual to population scale, and effective communication between exposure scientists and relevant stakeholders and policymakers, as part of the European Exposure Science Strategy 2020–2030.
- A human biomonitoring (HBM) Global Registry Framework: further advancement of HBM research following the FAIR principlesPublication . Zare Jeddi, Maryam; Virgolino, Ana; Fantke, Peter; Hopf, Nancy B.; Galea, Karen S.; Remy, Sylvie; Viegas, Susana; Mustieles, Vicente; Fernandez, Mariana F.; von Goetz, Natalie; Vicente, Joana Lobo; Slobodnik, Jaroslav; Rambaud, Loïc; Denys, Sébastien; St-Amand, Annie; Nakayama, Shoji F.; Santonen, Tiina; Barouki, Robert; Pasanen-Kase, Robert; Mol, Hans G.J.; Vermeire, Theo; Jones, Kate; Silva, Maria João; Louro, Henriqueta; van der Voet, Hilko; Duca, Radu-Corneliu; Verhagen, Hans; Canova, Cristina; van Klaveren, Jacob; Kolossa-Gehring, Marike; Bessems, JosData generated by the rapidly evolving human biomonitoring (HBM) programs are providing invaluable opportunities to support and advance regulatory risk assessment and management of chemicals in occupational and environmental health domains. However, heterogeneity across studies, in terms of design, terminology, biomarker nomenclature, and data formats, limits our capacity to compare and integrate data sets retrospectively (reuse). Registration of HBM studies is common for clinical trials; however, the study designs and resulting data collections cannot be traced easily. We argue that an HBM Global Registry Framework (HBM GRF) could be the solution to several challenges hampering the (re)use of HBM (meta)data. The aim is to develop a global, host-independent HBM registry framework based on the use of harmonized open-access protocol templates from designing, undertaking an HBM study to the use and possible reuse of the resulting HBM (meta)data. This framework should apply FAIR (Findable, Accessible, Interoperable, and Reusable) principles as a core data management strategy to enable the (re)use of HBM (meta)data to its full potential through the data value chain. Moreover, we believe that the implementation of FAIR principles is a fundamental enabler for digital transformation within environmental health. The HBM GRF would encompass internationally harmonized and agreed open access templates for HBM study protocols, structured web-based functionalities to deposit, find, and access harmonized protocols of HBM studies. Registration of HBM studies using the HBM GRF is anticipated to increase the FAIRness of the resulting (meta)data. It is also considered that the harmonization of existing data sets could be performed retrospectively. As a consequence, data wrangling activities to make data ready for analysis will be minimized. In addition, this framework would enable the HBM (inter)national community to trace new HBM studies already in the planning phase and their results once finalized. The HBM GRF could also serve as a platform enhancing communication between scientists, risk assessors, and risk managers/policymakers. The planned European Partnership for the Assessment of Risk from Chemicals (PARC) works along these lines, based on the experience obtained in previous joint European initiatives. Therefore, PARC could very well bring the first demonstration of the first essential functionalities within the development of the HBM GRF.