Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.21/652
Título: Formaldehyde's genotoxicity effects in pathology anatomy technologists and medical pathologists
Autor: Ladeira, Carina
Viegas, Susana
Prista, J.
Gomes, Manuel C.
Brito, Miguel
Palavras-chave: Anatomia patológica
Saúde ocupacional
Meio laboratorial
Biomarcador tumoral
Data: Set-2011
Citação: Ladeira C, Viegas S, Prista J, Gomes MC, Brito M. Formaldehyde's genotoxicity effects in pathology anatomy technologists and medical pathologists. In The European Environmental Mutagens Society, Oslo (Norway), 15th to 18th September 2011. Poster.
Resumo: Formaldehyde (FA) had been considered to be carcinogenic by the International Agency for Research on Cancer (group1), on the basis of sufficient evidence both in humans and in experimental animals, making it a subject of major environmental concern, especially in the occupational context. Manifold in vitro studies clearly indicated that FA is genotoxic, inducing various genotoxic effects in proliferating cultured mammalian cells. Cytokinesis-blocked micronucleus (CBMN) assay is used extensively in molecular epidemiology, and the chromosomal alterations most reported and studied by the CBMN are: micronucleus (MN), nucleoplasmic bridges (NPB) and nuclear buds (NBUDs). The pathology anatomy laboratories are work places that manipulate routinely FA and pathology anatomy technologists and pathologists contact daily with this chemical compound particularly in the macroscopic exam and grossing procedures. The aim of this study was to identify genotoxicity biomarkers in the set workers groups, such as micronucleus (MN), nucleoplasmic bridges (NPB) and nuclear buds (NBUD) in peripheral blood lymphocytes.
Peer review: yes
URI: http://hdl.handle.net/10400.21/652
Aparece nas colecções:ESTeSL - Posters

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