Utilize este identificador para referenciar este registo: http://hdl.handle.net/10400.21/646
Título: Effects of age and gender on peripheral lymphocyte micronucleus
Autor: Ladeira, Carina
Viegas, Susana
Gomes, Manuel C.
Brito, Miguel
Palavras-chave: Anatomia patológica
Saúde ocupacional
Factor de risco
Data: Jun-2011
Citação: Ladeira C, Viegas S, Gomes MC, Brito M. Effects of age and gender on peripheral lymphocyte micronucleus. In 21st Meeting of the European Association for Cancer Research, Oslo (Norway), 26th to 29th June 2011. Poster.
Resumo: Aging in humans appears to be associated with genetic instability. The cytokinesis-blocked micronucleus assay (CBMN) is a comprehensive method for measuring chromosome breakage, DNA misrepair, chromosome loss, non-disjunction, necrosis, apoptosis and cytostasis. Age and gender are the most important demographic variables affecting the micronucleus (MN) index and studies report frequencies in females being greater than those in males by a factor of 1.2 to 1.6 depending on the age group. It has been shown that a higher MN frequency directly corresponds to a decreased efficiency of DNA repair and increased genome instability.
Peer review: yes
URI: http://hdl.handle.net/10400.21/646
Aparece nas colecções:ESTeSL - Posters

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