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Effects of age and gender on peripheral lymphocyte micronucleus

2011-06Documento de conferência Acesso aberto
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dc.contributor.authorLadeira, Carina
dc.contributor.authorViegas, Susana
dc.contributor.authorGomes, Manuel C.
dc.contributor.authorBrito, Miguel
dc.date.accessioned2011-11-28T10:24:07Z
dc.date.available2011-11-28T10:24:07Z
dc.date.issued2011-06
dc.description.abstractAging in humans appears to be associated with genetic instability. The cytokinesis-blocked micronucleus assay (CBMN) is a comprehensive method for measuring chromosome breakage, DNA misrepair, chromosome loss, non-disjunction, necrosis, apoptosis and cytostasis. Age and gender are the most important demographic variables affecting the micronucleus (MN) index and studies report frequencies in females being greater than those in males by a factor of 1.2 to 1.6 depending on the age group. It has been shown that a higher MN frequency directly corresponds to a decreased efficiency of DNA repair and increased genome instability.por
dc.identifier.citationLadeira C, Viegas S, Gomes MC, Brito M. Effects of age and gender on peripheral lymphocyte micronucleus. In 21st Meeting of the European Association for Cancer Research, Oslo (Norway), 26th to 29th June 2011. Poster.por
dc.identifier.urihttp://hdl.handle.net/10400.21/646
dc.language.isoengpor
dc.peerreviewedyespor
dc.subjectAnatomia patológicapor
dc.subjectSaúde ocupacionalpor
dc.subjectDNApor
dc.subjectFactor de riscopor
dc.titleEffects of age and gender on peripheral lymphocyte micronucleuspor
dc.typeconference object
dspace.entity.typePublication
person.familyNameLadeira
person.familyNameViegas
person.familyNameBrito
person.givenNameCarina
person.givenNameSusana
person.givenNameMiguel
person.identifier144237
person.identifier248817
person.identifier.ciencia-id801C-1BBA-1D9E
person.identifier.ciencia-idA919-7318-63DC
person.identifier.ciencia-id231F-F341-7E93
person.identifier.orcid0000-0001-5588-0074
person.identifier.orcid0000-0003-1015-8760
person.identifier.orcid0000-0001-6394-658X
person.identifier.ridJ-2572-2012
person.identifier.ridI-4053-2012
person.identifier.ridA-7970-2016
person.identifier.scopus-author-id36463788000
person.identifier.scopus-author-id35270591500
person.identifier.scopus-author-id35224551000
rcaap.rightsopenAccesspor
rcaap.typeconferenceObjectpor
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relation.isAuthorOfPublication.latestForDiscovery13115332-43f7-4048-a8a5-2f2b855a8c92

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