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Assessing the impact of nanoplastics in biological systems: systematic review of in vitro animal studies

2025-05Journal article Open access
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datacite.subject.sdg03:Saúde de Qualidade
dc.contributor.authorViana, Maria
dc.contributor.authorTonin, Fernanda
dc.contributor.authorLadeira, Carina
dc.date.accessioned2025-06-05T10:52:14Z
dc.date.available2025-06-05T10:52:14Z
dc.date.issued2025-05
dc.descriptionThis research was funded by the Instituto Politécnico de Lisboa (grant IPL/2021/PLASCOGEN_ESTeSL). The H&TRC authors acknowledge FCT/MCTES UIDP/05608/2020 and UIDB/05608/2020.
dc.description.abstractNanoplastic (NP) pollution has emerged as a growing concern due to its potential impact on human health, although its adverse effects on different organ systems are not yet fully understood. This systematic scoping review, conducted following international guidelines, aimed to map the current evidence on the biological effects of NPs. In vitro animal studies assessing cellular damage caused by exposure to any type of NP were searched on PubMed, Web of Science, and Scopus. Data on primary outcomes related to genotoxicity and cytotoxicity (cell viability, oxidative stress, inflammation, DNA and cytoplasmic damage, apoptosis) were extracted from the included studies, and overall reporting quality was assessed. A total of 108 articles published between 2018 and 2024, mostly by China (54%), Spain (14%), and Italy (9%), were included. Polystyrene (PS) was the most frequently studied polymer (85%). NP sizes in solution ranged from 15 to 531 nm, with a higher prevalence in the 40–100 nm range (38%). The overall quality of studies was rated as moderate (60%), with many lacking essential details about cell culture conditions (e.g., pH of the medium, passage number, substances used). A higher frequency of negative effects from NP exposure was observed in respiratory cell lines, while immune, digestive, and hepatic cell lines showed greater resistance. Nervous, urinary, and connective tissue systems were impacted by NPs. Positively charged and smaller PS particles were consistently associated with higher toxicity across all systems. In summary, this review highlights the multifactorial nature of NP toxicity, influenced by size, surface charge, and polymer type. It also reveals a significant knowledge gap, stemming from the predominant use of immortalized monocultures exposed to commercially available PS NPs, the limited use of environmentally relevant particles, and the underutilization of advanced experimental models (e.g., organ-on-chip systems) that better mimic physiological conditions.eng
dc.identifier.citationViana M, Tonin FS, Ladeira C. Assessing the impact of nanoplastics in biological systems: systematic review of in vitro animal studies. J Xenobiot. 2025;15(3):75.
dc.identifier.doi10.3390/jox15030075
dc.identifier.issn2039-4713
dc.identifier.urihttp://hdl.handle.net/10400.21/21908
dc.language.isoeng
dc.peerreviewedyes
dc.publisherMDPI AG
dc.relation.hasversionhttps://www.mdpi.com/2039-4713/15/3/75
dc.relation.ispartofJournal of Xenobiotics
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectCellular lines
dc.subjectCytoxicity
dc.subjectIn vitro
dc.subjectNanoplastics
dc.subjectOrgan system
dc.subjectSystematic review
dc.subjectIPL/2021/PLASCOGEN_ESTeSL
dc.subjectFCT_UIDP/05608/2020
dc.subjectFCT_UIDB/05608/2020
dc.titleAssessing the impact of nanoplastics in biological systems: systematic review of in vitro animal studieseng
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue3
oaire.citation.startPage75
oaire.citation.titleJournal of Xenobiotics
oaire.citation.volume15
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameTonin
person.familyNameLadeira
person.givenNameFernanda
person.givenNameCarina
person.identifier144237
person.identifier.ciencia-idD01C-C700-9411
person.identifier.ciencia-id801C-1BBA-1D9E
person.identifier.orcid0000-0003-4262-8608
person.identifier.orcid0000-0001-5588-0074
person.identifier.ridO-2050-2017
person.identifier.ridJ-2572-2012
person.identifier.scopus-author-id56085115800
person.identifier.scopus-author-id36463788000
relation.isAuthorOfPublication61ded30e-ecec-4b3e-b953-2293e080ebdd
relation.isAuthorOfPublication1aef4b60-4197-436b-84ab-80d31cbaed33
relation.isAuthorOfPublication.latestForDiscovery61ded30e-ecec-4b3e-b953-2293e080ebdd

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