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Potential anti-inflammatory effect of Rosmarinus officinalis in preclinical in vivo models of inflammation

2022-01Journal article Open access
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dc.contributor.authorGonçalves, Catarina
dc.contributor.authorFernandes, Daniela
dc.contributor.authorSilva, Inês
dc.contributor.authorMateus, Vanessa
dc.date.accessioned2022-02-10T12:03:03Z
dc.date.available2022-02-10T12:03:03Z
dc.date.issued2022-01
dc.descriptionFCT_UIDB/05608/2020. FCT_UIDP/05608/2020.pt_PT
dc.description.abstractThis systematic review aimed to evaluate the potential anti-inflammatory effect of Rosmarinus officinalis in preclinical in vivo models of inflammation. A search was conducted in the databases PubMed, Scopus, and Web of Science, with related keywords. The inclusion criteria were inflammation, plant, and studies on rats or mice; while, the exclusion criteria were reviews, studies with in vitro models, and associated plants. The predominant animal models were paw edema, acute liver injury, and asthma. Rosemary was more commonly used in its entirety than in compounds, and the prevalent methods of extraction were maceration and hydrodistillation. The most common routes of administration reported were gavage, intraperitoneal, and oral, on a route-dependent dosage. The treatment took place daily, or was single-dose, on average for 21 days, and it more often started before the induction. The most evaluated biomarkers were tumor necrosis factor (TNF)-α, interleukin (IL)-1β, IL-6, IL-10, myeloperoxidase (MPO), catalase (CAT), glutathione (GSH), glutathione peroxidase (GPx), malondialdehyde (MDA), and superoxide dismutase (SOD). The best results emerged at a dose of 60 mg/kg, via IP of carnosic acid, a dose of 400 mg/kg via gavage of Rosmarinus officinalis, and a dose of 10 mg/kg via IP of rosmarinic acid. Rosmarinus officinalis L. showed anti-inflammatory activity before and after induction of treatments.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationGonçalves C, Fernandes D, Silva IJ, Mateus V. Potential anti-inflammatory effect of Rosmarinus officinalis in preclinical in vivo models of inflammation. Molecules. 2022;27(3):609.pt_PT
dc.identifier.doi10.3390/molecules27030609pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/14282
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationFCT_UIDB/05608/2020pt_PT
dc.relationFCT_UIDP/05608/2020pt_PT
dc.relation.publisherversionhttps://www.mdpi.com/1420-3049/27/3/609pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectInflammationpt_PT
dc.subjectRosmarinus officinalis Lpt_PT
dc.subjectRosmarinuspt_PT
dc.subjectRosmarinic acidpt_PT
dc.subjectCarnosic acidpt_PT
dc.subjectCarnosolpt_PT
dc.subjectRatspt_PT
dc.subjectMicept_PT
dc.subjectMousept_PT
dc.subjectFCT_UIDB/05608/2020pt_PT
dc.subjectFCT_UIDP/05608/2020pt_PT
dc.titlePotential anti-inflammatory effect of Rosmarinus officinalis in preclinical in vivo models of inflammationpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue3pt_PT
oaire.citation.startPage609pt_PT
oaire.citation.titleMoleculespt_PT
oaire.citation.volume27pt_PT
person.familyNameda Silva
person.familyNamePinho Mateus
person.givenNameInês Filipa Janeiro da Silva
person.givenNameVanessa Alexandra
person.identifier.ciencia-idC010-323F-3266
person.identifier.ciencia-id5A12-571D-AD6A
person.identifier.orcid0000-0001-7049-2512
person.identifier.orcid0000-0002-3204-3772
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication995e1831-ff5b-49e7-a6e3-8bc692212204
relation.isAuthorOfPublication406041a5-682c-4f94-a4e2-ddbfc541313c
relation.isAuthorOfPublication.latestForDiscovery406041a5-682c-4f94-a4e2-ddbfc541313c

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