Repository logo
 
Publication

Methodological quality of pulmonary arterial hypertension treatment evidence-based guidelines: a systematic review using the AGREE II and AGREE REX tools

2024-07Journal article Open access
Simple item page
dc.contributor.authorVilela, Ana Paula
dc.contributor.authorDeffert, Flávia
dc.contributor.authorLucchetta, Rosa Camila
dc.contributor.authorPires, Yara Maria
dc.contributor.authorMainka, Felipe Fernando
dc.contributor.authorTonin, Fernanda
dc.contributor.authorPontarolo, Roberto
dc.date.accessioned2024-07-24T09:35:53Z
dc.date.available2024-07-24T09:35:53Z
dc.date.issued2024-07
dc.description.abstractPurpose: Pulmonary arterial hypertension (PAH) is a progressive disease with a poor prognosis, and its management should be grounded in well-developed clinical practice guidelines (CPG). Thus, we critically assess the methodological quality of the available CPG for pharmacological treatments for PAH. Methods: A systematic review (CRD42023387168) was performed in PubMed, Cochrane, Embase, and Tripdatabase (Jan-2023). Eligible records were appraised by four reviewers using the Appraisal of Guidelines, Research, and Evaluation Collaboration tool (AGREE II) and the complementary tool for assessing recommendations' quality and certainty, AGREE REX. Descriptive statistics were used to summarize the data. Results: Overall, 31 guidelines, mainly authored by professional societies (90%), targeting only physicians as primary users (84%), were identified. Guidelines presented a moderate overall quality (scores of 63% and 51% in AGREE II and AGREE REX, respectively), with a few domains showing slight improvements over the years. AGREE II "Scope and Purpose" (94%) and "Presentation Clarity" (99%) domains obtained the highest scores. The items related to "Stakeholder involvement," "Editorial independence," and "Clinical applicability" (AGREE REX) were fairly reported. Conversely, CPG lacks rigor in development (32% score, AGREE II), scarcely discusses the role of stakeholders, and provides deficient data on the implementation of recommendations (scores of 35% and 46% in AGREE II and AGREE REX, respectively). No differences in the quality of guidelines published by different developers or countries were observed (p > 0.05). Conclusion: Methodological weaknesses are common among guidelines addressing PAH treatment, especially regarding scientific rigor, stakeholders' values and preferences, and facilitators and barriers to implementability. Particular attention should be given to developing future guidelines.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationVilela AP, Deffert F, Lucchetta RC, Pires YM, Mainka FF, Tonin FS, et al. Methodological quality of pulmonary arterial hypertension treatment evidence-based guidelines: a systematic review using the AGREE II and AGREE REX tools. Cardiovasc Drugs Ther. 2024 July 9. Epub ahead of print.pt_PT
dc.identifier.doi10.1007/s10557-024-07605-wpt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/17583
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringerpt_PT
dc.relation.publisherversionhttps://link.springer.com/article/10.1007/s10557-024-07605-wpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectAGREE IIpt_PT
dc.subjectAGREE REXpt_PT
dc.subjectPractice guidelinept_PT
dc.subjectPulmonary arterial hypertensionpt_PT
dc.subjectQuality assessmentpt_PT
dc.titleMethodological quality of pulmonary arterial hypertension treatment evidence-based guidelines: a systematic review using the AGREE II and AGREE REX toolspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.titleCardiovascular Drugs and Therapypt_PT
person.familyNameTonin
person.givenNameFernanda
person.identifier.ciencia-idD01C-C700-9411
person.identifier.orcid0000-0003-4262-8608
person.identifier.ridO-2050-2017
person.identifier.scopus-author-id56085115800
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication61ded30e-ecec-4b3e-b953-2293e080ebdd
relation.isAuthorOfPublication.latestForDiscovery61ded30e-ecec-4b3e-b953-2293e080ebdd

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
Methodological quality of pulmonary arterial hypertension treatment evidence-based guidelines_a systematic review using the AGREE II and AGREE REX tools.pdf
Size:
1.09 MB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

ESTeSL - Artigos