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  • Association between lung function and dyspnoea and its variation in the multinational Burden of Obstructive Lung Disease (BOLD) study
    Publication . Müller, A.; Wouters, E. F.; Koul, P.; Welte, T.; Harrabi, I.; Rashid, A.; Loh, L. C.; Al Ghobain, M.; Elsony, A.; Ahmed, R.; Potts, J.; Mortimer, K.; Rodrigues, F.; Paraguas, S. N.; Juvekar, S.; Agarwal, D.; Obaseki, D.; Gislason, T.; Seemungal, T.; Nafees, A. A.; Jenkins, C.; Dias, Hermínia Brites; Franssen, F. M.; Studnicka, M.; Janson, C.; Cherkaski, H. H.; El Biaze, M.; Mahesh, P. A.; Cardoso, João; Burney, P.; Hartl, S.; Janssen, D. J.; Amaral, A. F.
    Background: Dyspnoea is a common symptom of respiratory disease. However, data on its prevalence in general populations and its association with lung function are limited and are mainly from high-income countries. This study aimed to estimate the prevalence of dyspnoea across several world regions and to investigate the association of dyspnoea with lung function. Methods: Dyspnoea was assessed, and lung function was measured in 25,806 adult participants of the multinational Burden of Obstructive Lung Disease study. Dyspnoea was defined as ≥2 on the modified Medical Research Council (mMRC) dyspnoea scale. The prevalence of dyspnoea was estimated for each of the study sites and compared across countries and world regions. Multivariable logistic regression was used to assess the association of dyspnoea with lung function in each site. Results were then pooled using random-effects meta-analysis. Results: The prevalence of dyspnoea varied widely across sites without a clear geographical pattern. The mean prevalence of dyspnoea was 13.7 % (SD=8.2 %), ranging from 0 % in Mysore (India) to 28.8 % in Nampicuan-Talugtug (Philippines). Dyspnoea was strongly associated with both spirometry restriction (FVC
    2025-12Journal article Open access Show more
  • Enhancing the performance of double-flush riveted joints through hybridization with adhesive bonding
    Publication . Alpendre, João M. B.; Rosado, Pedro M. S.; Sampaio, Rui F. V.; Pragana, João P. M.; Bragança, Ivo; Silva, Carlos M. A.; Martins, Paulo A. F.
    This paper explores the potential to enhance the mechanical performance of joints created through a new joining-by-forming technique called hybrid double-flush riveting. To achieve this, adhesive bonding is used to form hybrid lap joints with superior mechanical properties. The study focuses on high-strength steel sheets and starts by identifying the appropriate surface conditions necessary for producing strong adhesive-bonded joints. A similar strategy is applied to construct double-flush riveted joints, focusing on the geometric variables involved in the process. Hybrid joints are then created by integrating adhesive bonding with double-flush riveting, with the second carried out before or after curing is completed. The experimental development is supported by finite element analysis conducted with an in-house computer program. The mechanical performance of the hybrid joints is compared to that of purely adhesive-bonded and conventionally double-flush riveted joints through shear and peel destructive testing. Results demonstrate that hybrid joints ultimately provide greater joint strength for both solicitations. This allows showcasing the hybridization of double-flush riveting with adhesive bonding as an effective solution for applications where joint strength and continuity are essential.
    2025-12Research article Restricted access Show more