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Impact of annual albendazole versus four-monthly test-and-treat approach of intestinal parasites on children growth: a longitudinal four-arm randomized parallel trial during two years of a community follow-up in Bengo, Angola

2021-03Journal article Open access
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dc.contributor.authorGasparinho, Carolina
dc.contributor.authorKanjungo, Aguinaldo
dc.contributor.authorZage, Félix
dc.contributor.authorClemente, Isabel
dc.contributor.authorSantos-Reis, Ana
dc.contributor.authorBrito, Miguel
dc.contributor.authorSousa-Figueiredo, José Carlos
dc.contributor.authorFortes, Filomeno
dc.contributor.authorGonçalves, Luzia
dc.date.accessioned2021-03-08T11:08:24Z
dc.date.available2021-03-08T11:08:24Z
dc.date.issued2021-03
dc.description.abstractMalnutrition and intestinal parasites continue to have serious impacts on the growth and cognitive development of children in Angola. A longitudinal four-arm randomized parallel trial was conducted to investigate if deworming with a single annual dose of albendazole (annual-ALB) or a four-monthly test-and-treat (4TT) intestinal parasites approach at an individual or household levels improve nutritional outcomes of pre-school children in Bengo province. Children with intestinal parasites (n = 121) were randomly assigned (1:1:1:1) to arm A1: annual-ALB*individual level; A2: annual-ALB*household level; A3: 4TT*individual; and A4: 4TT*household level. At baseline, 4, 8, 12, 16, 20, and 24 months of follow-up, growth was assessed by height, weight, height-for-age, weight-for-height, weight-for-age, and mid-upper arm circumference. Intention-to-treat analysis was done using a non-parametric approach, mixed effect models, and generalized estimating equations (GEE). Initially, 57% and 26% of the children were infected by Giardia lamblia and Ascaris lumbricoides, respectively. This study did not show that a 4TT intestinal parasites approach results in better growth outcomes of children (height, weight, HAZ, WAZ, WHZ, and MUACZ) when compared with annual ALB, with exception of height and WHZ using the GEE model at 5% level. Positive temporal effects on most nutrition outcomes were observed. Implementing a longitudinal study in a poor setting is challenging and larger sample sizes and ‘pure and clean’ data are difficult to obtain. Nevertheless, learned lessons from this intensive study may contribute to future scientific research and tailor multidisciplinary approaches to minimize malnutrition and infections in resource-poor countries.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationGasparinho C, Kanjungo A, Zage F, Clemente I, Santos-Reis A, Brito M, et al. Impact of annual albendazole versus four-monthly test-and-treat approach of intestinal parasites on children growth: a longitudinal four-arm randomized parallel trial during two years of a community follow-up in Bengo, Angola. Pathogens. 2021;10(3):309.pt_PT
dc.identifier.doi10.3390/pathogens10030309pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/13052
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relation.publisherversionhttps://www.mdpi.com/2076-0817/10/3/309pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectStuntingpt_PT
dc.subjectZ-scorept_PT
dc.subjectGrowthpt_PT
dc.subjectLongitudinal randomized trialpt_PT
dc.subjectDewormingpt_PT
dc.subjectIntestinal parasitept_PT
dc.subjectAlbendazolept_PT
dc.subjectAngolapt_PT
dc.subjectProvíncia do Bengopt_PT
dc.titleImpact of annual albendazole versus four-monthly test-and-treat approach of intestinal parasites on children growth: a longitudinal four-arm randomized parallel trial during two years of a community follow-up in Bengo, Angolapt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue3pt_PT
oaire.citation.startPage309pt_PT
oaire.citation.titlePathogenspt_PT
oaire.citation.volume10pt_PT
person.familyNameGasparinho
person.familyNameBrito
person.familyNameGonçalves
person.givenNameCarolina
person.givenNameMiguel
person.givenNameLuzia
person.identifier1478293
person.identifier.ciencia-id2B18-71C3-C277
person.identifier.ciencia-id231F-F341-7E93
person.identifier.orcid0000-0002-0095-6155
person.identifier.orcid0000-0001-6394-658X
person.identifier.orcid0000-0002-9710-1945
person.identifier.ridA-7970-2016
person.identifier.scopus-author-id57074028100
person.identifier.scopus-author-id35224551000
person.identifier.scopus-author-id7103169188
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationdcd728c6-e432-4bf6-9638-398b1e25f129
relation.isAuthorOfPublication4252d8e0-800c-4d67-8b13-0b711d860669
relation.isAuthorOfPublication5351d25c-e761-46a4-be0f-4ae5325535bf
relation.isAuthorOfPublication.latestForDiscovery5351d25c-e761-46a4-be0f-4ae5325535bf

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