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The use of genotoxicity biomarkers in molecular epidemiology: applications in environmental, occupational and dietary studies

2017-08Journal article Open access
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dc.contributor.authorLadeira, Carina
dc.contributor.authorSmajdova, Lenka
dc.date.accessioned2017-08-16T17:04:38Z
dc.date.available2017-08-16T17:04:38Z
dc.date.issued2017-08
dc.description.abstractMolecular epidemiology is an approach increasingly used in the establishment of associations between exposure to hazardous substances and development of disease, including the possible modulation by genetic susceptibility factors. Environmental chemicals and contaminants from the anthropogenic pollution of air, water, and soil, but also originating specifically in occupational contexts, are potential sources of risk of development of the disease. Also, diet presents an important role in this process, with some well-characterized associations existing between nutrition and some types of cancer. Genotoxicity biomarkers allow the detection of early effects that result from the interaction between the individual and the environment; they are therefore important tools in cancer epidemiology and are extensively used in human biomonitoring studies. This work intends to give an overview of the potential for genotoxic effects assessment, specifically with the cytokinesis blocked micronucleus assay and comet assay in environmental and occupational scenarios, including diet. The plasticity of these techniques allows their inclusion in human biomonitoring studies, adding important information with the ultimate aim of disease prevention, in particular cancer, and so it is important that they are included as genotoxicity assays in molecular epidemiology.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationLadeira C, Smajdova L. The use of genotoxicity biomarkers in molecular epidemiology: applications in environmental, occupational and dietary studies. AIMS Genetics. 2017;4(3):166-91.pt_PT
dc.identifier.doi10.3934/genet.2017.3.166pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/7324
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherAIMS Presspt_PT
dc.relation.publisherversionhttp://www.aimspress.com/Genetics/2017/3/166pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectMolecular epidemiologypt_PT
dc.subjectBiomarkerspt_PT
dc.subjectGenotoxicitypt_PT
dc.subjectMicronucleipt_PT
dc.subjectComet assaypt_PT
dc.subjectEnvironmentpt_PT
dc.subjectDietpt_PT
dc.titleThe use of genotoxicity biomarkers in molecular epidemiology: applications in environmental, occupational and dietary studiespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage191pt_PT
oaire.citation.issue3pt_PT
oaire.citation.startPage166pt_PT
oaire.citation.titleAIMS Geneticspt_PT
oaire.citation.volume4pt_PT
person.familyNameLadeira
person.givenNameCarina
person.identifier144237
person.identifier.ciencia-id801C-1BBA-1D9E
person.identifier.orcid0000-0001-5588-0074
person.identifier.ridJ-2572-2012
person.identifier.scopus-author-id36463788000
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication1aef4b60-4197-436b-84ab-80d31cbaed33
relation.isAuthorOfPublication.latestForDiscovery1aef4b60-4197-436b-84ab-80d31cbaed33

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